Antibody Formation by Transplanted Bone Marrow, Spleen, Lymph Node and Thymus Cells in Irradiated Recipients

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Description

The role of the marrow as a site for antibody formation has been considered for many years. In 1912 Ludke reported the appearance of antibody in cultures of marrow cells obtained from previously immunized rabbits. Specific agglutinins for killed typhoid bacilli and lysins for ox red cells and sheep red cells were detected in the culture media 2 to 5 days later. However, the cultured cells failed to produce antibody when these antigens were added to the media. Similar findings by Reiter, Przygode, and Schilf appeared in the early literature with regard to the appearance of antibodies to various antigens … continued below

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Stoner, Richard D. & Bond, Victor P. February 25, 1963.

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  • Main Title: Antibody Formation by Transplanted Bone Marrow, Spleen, Lymph Node and Thymus Cells in Irradiated Recipients
  • Series Title: BNL (Series)
  • Series Title: Brookhaven National Laboratory Reports
  • Added Title: Brookhaven National Laboratory Report BNL-6649

Description

The role of the marrow as a site for antibody formation has been considered for many years. In 1912 Ludke reported the appearance of antibody in cultures of marrow cells obtained from previously immunized rabbits. Specific agglutinins for killed typhoid bacilli and lysins for ox red cells and sheep red cells were detected in the culture media 2 to 5 days later. However, the cultured cells failed to produce antibody when these antigens were added to the media. Similar findings by Reiter, Przygode, and Schilf appeared in the early literature with regard to the appearance of antibodies to various antigens in tissue cultures of bone marrow from immunized animals, along with failure to elicit antibody formation by addition of antigen to the culture resulted from the addition of excess amounts of antigen, so that if antibody synthesis occurred, the excess antigen combined with antibody and significant amounts of free antibody could not be detected in the culture media. Thorbecke and Keuning observed an increase in antibody in culture fluids when bone marrow fragments from rabbits immunized to paratyphoid B vaccine were cultured in roller tubes.

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  • February 25, 1963

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  • Feb. 5, 2022, 9:55 a.m.

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Stoner, Richard D. & Bond, Victor P. Antibody Formation by Transplanted Bone Marrow, Spleen, Lymph Node and Thymus Cells in Irradiated Recipients, report, February 25, 1963; Washington D.C.. (https://digital.library.unt.edu/ark:/67531/metadc1255813/: accessed May 17, 2025), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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