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Tissue Distribution and Storage Forms of Vitamin B12 Injected and Orally Administered to the Dog

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Previous attempts by the present authors to compare the behavior of orally administered vitamin B12 with that of injected material have been inconclusive. Thus, 30 days after administration to normal humans, 0.19% of a tracer amount (0.5 μg) of injected radioactive vitamin B12 is excreted per day; and in an independent study, the eventual daily output was found to be 0.23% of a 3 μg dose. By contrast the total excretion rate of normal vitamin B12 from body stores appears to be only ≈0.03% per day. Such a divergence may result from incomplete mixing of radioactive vitamin B12 and body … continued below

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Rosenblum, Charles; Reizenstein, Peter G.; Cronicite, Eugene P. & Meriwether, Henry T. February 1, 1963.

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  • Main Title: Tissue Distribution and Storage Forms of Vitamin B12 Injected and Orally Administered to the Dog
  • Series Title: BNL (Series)
  • Series Title: Brookhaven National Laboratory Reports
  • Added Title: Brookhaven National Laboratory Report BNL-6588

Description

Previous attempts by the present authors to compare the behavior of orally administered vitamin B12 with that of injected material have been inconclusive. Thus, 30 days after administration to normal humans, 0.19% of a tracer amount (0.5 μg) of injected radioactive vitamin B12 is excreted per day; and in an independent study, the eventual daily output was found to be 0.23% of a 3 μg dose. By contrast the total excretion rate of normal vitamin B12 from body stores appears to be only ≈0.03% per day. Such a divergence may result from incomplete mixing of radioactive vitamin B12 and body stores of the vitamin. Alternatively it may actually reflect the functioning of different compartments attending the several modes of administration involved. The possibility of degradation or transformation of vitamin within tissues and organs must also be considered.

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  • February 1, 1963

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  • Feb. 5, 2022, 9:42 a.m.

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  • Oct. 4, 2022, 3:56 a.m.

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Rosenblum, Charles; Reizenstein, Peter G.; Cronicite, Eugene P. & Meriwether, Henry T. Tissue Distribution and Storage Forms of Vitamin B12 Injected and Orally Administered to the Dog, report, February 1, 1963; Washington D.C.. (https://digital.library.unt.edu/ark:/67531/metadc1250514/: accessed December 14, 2025), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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