Radioactive Drug Research, Final Summary Report, July 1949 to October 1959

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Description

Applications of radioisotopes in the preparation of labeled drugs are reviewed. Among the applications described are the preparation of carbon-14- labeled cardiac glycosides, and the biosyinthesis of carbon-14-labeled digitoxin, morphine, colchicine, atropine, podophyllotoxin, and nicotine. The fate and metabolism of many of these drugs were traced. Radiochemical procedures were developed for the synthesis of pure compounds of pharmacological interest labeled with carbon-14, sulfur-35, and tritium. Investigations were made on the phenomena of drug penetration into the central nervous system. Publications during the period are listed. (C.H.)

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12 pages

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Geiling, E. M. K. (Eugene Maximilian Karl), 1891-1971 & Roth, Lloyd J. (Lloyd Joseph), 1911- January 15, 1960.

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Applications of radioisotopes in the preparation of labeled drugs are reviewed. Among the applications described are the preparation of carbon-14- labeled cardiac glycosides, and the biosyinthesis of carbon-14-labeled digitoxin, morphine, colchicine, atropine, podophyllotoxin, and nicotine. The fate and metabolism of many of these drugs were traced. Radiochemical procedures were developed for the synthesis of pure compounds of pharmacological interest labeled with carbon-14, sulfur-35, and tritium. Investigations were made on the phenomena of drug penetration into the central nervous system. Publications during the period are listed. (C.H.)

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12 pages

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  • Report No.: AECU-4618
  • Grant Number: AT(11-1)-45
  • SuDoc Number: Y 3.At 7:22/AECU-4618
  • Accession or Local Control No: metadc1248772
  • Archival Resource Key: ark:/67531/metadc1248772

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  • January 15, 1960

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  • July 9, 2023, 6:07 p.m.

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  • March 13, 2024, 11:44 a.m.

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Thumbnail image of item number 1 in: 'Radioactive Drug Research, Final Summary Report, July 1949 to October 1959'.
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Geiling, E. M. K. (Eugene Maximilian Karl), 1891-1971 & Roth, Lloyd J. (Lloyd Joseph), 1911-. Radioactive Drug Research, Final Summary Report, July 1949 to October 1959, report, January 15, 1960; Washington D.C.. (https://digital.library.unt.edu/ark:/67531/metadc1248772/: accessed April 29, 2025), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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