Functions of Aging. Insolubilization of Protein as a Function of Aging. Final Report

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Description

Whole-body x irradiation was used to accelerate the onset of senescence in female white rats. Comparisons of nonirradiated and irradiated tissues have been made using histological, physical, and enzyme techniques. The data amassed to date indicate that x irradiation causes a reduction of 20.6 percent in alpha- amino nitrogen liberated by tryptic hydrolysis in liver homogenates. This reduction in amino nitrogen is not observed, however, in muscle homogenates. Shrinkage temperature determinations indicate that irradiation may result in cross-linking of rat tail tendons in a manner resembling nonirradiated mature tendons. It is felt, however, that irradiation has also severed peptide bonds … continued below

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34 pages : illustrations

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Bjorksten, Johan, 1907-; Andrews, Fred A.; Trenk, Bruce & Bailey, Julia March 31, 1959.

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  • Main Title: Functions of Aging. Insolubilization of Protein as a Function of Aging. Final Report
  • Series Title: AECU (Series)
  • Series Title: Atomic Energy Commission Reports
  • Added Title: Atomic Energy Commission Report AECU-4101

Description

Whole-body x irradiation was used to accelerate the onset of senescence in female white rats. Comparisons of nonirradiated and irradiated tissues have been made using histological, physical, and enzyme techniques. The data amassed to date indicate that x irradiation causes a reduction of 20.6 percent in alpha- amino nitrogen liberated by tryptic hydrolysis in liver homogenates. This reduction in amino nitrogen is not observed, however, in muscle homogenates. Shrinkage temperature determinations indicate that irradiation may result in cross-linking of rat tail tendons in a manner resembling nonirradiated mature tendons. It is felt, however, that irradiation has also severed peptide bonds in the collagen which complicate interpretation of the data. It is postulated that this observation may be useful both for a study of collagen structure and also as a clinical method for determining the extent of irradiation absorbed accidentally. (auth)

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34 pages : illustrations

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Digitized from microopaque cards (2).

Includes bibliographic references (pages 32-34).

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  • Report No.: AECU-4101
  • Grant Number: AT(11-1)-606
  • SuDoc Number: Y 3.At 7:22/AECU-4101
  • Accession or Local Control No: metadc1240532
  • Archival Resource Key: ark:/67531/metadc1240532

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TRAIL Microcard Collection

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  • March 31, 1959

Added to The UNT Digital Library

  • Nov. 5, 2023, 7:54 a.m.

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  • Sept. 17, 2024, 11:57 a.m.

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Bjorksten, Johan, 1907-; Andrews, Fred A.; Trenk, Bruce & Bailey, Julia. Functions of Aging. Insolubilization of Protein as a Function of Aging. Final Report, report, March 31, 1959; Washington D.C.. (https://digital.library.unt.edu/ark:/67531/metadc1240532/: accessed October 13, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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