The Association between Hantavirus Infection and Selenium Deficiency in Mainland China

PDF Version Also Available for Download.

Description

This article studies the role of selenium concentration in hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses, using a multidisciplinary approach combining ecological analysis with preliminary experimental data.

Physical Description

19 p.

Creation Information

Fang, Liqun; Goeijenbier, Marco; Zuo, Shu-Qing; Wang, Li-Ping; Liang, Song; Klein, Sabra L. et al. January 20, 2015.

Context

This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Arts and Sciences to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 44 times , with 7 in the last month . More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Authors

Publisher

Provided By

UNT College of Arts and Sciences

The UNT College of Arts and Sciences educates students in traditional liberal arts, performing arts, sciences, professional, and technical academic programs. In addition to its departments, the college includes academic centers, institutes, programs, and offices providing diverse courses of study.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Degree Information

Description

This article studies the role of selenium concentration in hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses, using a multidisciplinary approach combining ecological analysis with preliminary experimental data.

Physical Description

19 p.

Notes

Abstract: Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses and transmitted by rodents is a significant public health problem in China, and occurs more frequently in selenium-deficient regions. To study the role of selenium concentration in HFRS incidence we used a multidisciplinary approach combining ecological analysis with preliminary experimental data. The incidence of HFRS in humans was about six times higher in severe selenium-deficient and double in moderate deficient areas compared to non-deficient areas. This association became statistically stronger after correction for other significant environment-related factors (low elevation, few grasslands, or an abundance of forests) and was independent of geographical scale by separate analyses for different climate regions. A case-control study of HFRS patients admitted to the hospital revealed increased activity and plasma levels of selenium binding proteins while selenium supplementation in vitro decreased viral replication in an endothelial cell model after infection with a low multiplicity of infection (MOI). Viral replication with a higher MOI was not affected by selenium supplementation. Our findings indicate that selenium deficiency may contribute to an increased prevalence of hantavirus infections in both humans and rodents. Future studies are needed to further examine the exact mechanism behind this observation before selenium supplementation in deficient areas could be implemented for HFRS prevention.

Source

  • Viruses, 2015. Basel, Switzerland: Multidisciplinary Digital Publishing Institute

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

Publication Information

  • Publication Title: Viruses
  • Volume: 7
  • Page Start: 1
  • Page End: 19
  • Peer Reviewed: Yes

Collections

This article is part of the following collection of related materials.

UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • January 20, 2015

Submitted Date

  • October 27, 2014

Accepted Date

  • January 19, 2015

Added to The UNT Digital Library

  • Aug. 30, 2018, 9:08 a.m.

Usage Statistics

When was this article last used?

Yesterday: 1
Past 30 days: 7
Total Uses: 44

Where

Geographical information about where this article originated or about its content.

Place Name

Publication Place

Map Information

  • map marker Automatically generated Place Name coordinates.
  • map marker Automatically generated Publication Place coordinates.
  • Repositioning map may be required for optimal printing.

Mapped Locations

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Fang, Liqun; Goeijenbier, Marco; Zuo, Shu-Qing; Wang, Li-Ping; Liang, Song; Klein, Sabra L. et al. The Association between Hantavirus Infection and Selenium Deficiency in Mainland China, article, January 20, 2015; Basel, Switzerland. (https://digital.library.unt.edu/ark:/67531/metadc1234383/: accessed March 18, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT College of Arts and Sciences.