The neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line

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This article discusses the neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line.

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12 p.

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Duncan, Scott R.; Chapman, Kent D. & Koulen, Peter December 10, 2009.

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This article discusses the neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line.

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12 p.

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Abstract: Background: N-acylethanolamines (NAEs) are lipids upregulated in response to cell and tissue injury and are involved in cytoprotection. Arachidonylethanolamide (AEA) is a well characterized NAE that is an endogenous ligand at cannabinoid and vanilloid receptors, but it exists in small quantities relative to other NAE types. The abundance of other NAE species, such as palmitoylethanolamine (PEA), together with their largely unknown function and receptors, has prompted us to examine the neuroprotective properties and mechanism of action of PEA. The authors hypothesized that PEA protects HT22 cells from oxidative stress and activates neuroprotective kinase signaling pathways. Results: Indeed PEA protected HT22 cells from oxidative stress in part by mediating an increase in phosphorylated Akt (pAkt) and ERK 1/2 immunoreactivity as well as pAkt nuclear translocation. These changes take place within a time frame consistent with neuroprotection. Furthermore, the authors determined that changes in pAkt immunoreactivity elicited by PEA were not mediated by activation of cannabinoid receptor type 2 (CB2), thus indicating a novel mechanism of action. These results establish a role for PEA as a neuroprotectant against oxidative stress, which occurs in a variety of neurodegenerative diseases. Conclusions: The results from this study reveal that PEA protects HT22 cells from oxidative stress and alters the localization and expression levels of kinases known to be involved in neuroprotection by a novel mechanism. Overall, these results identify PEA as a neuroprotectant with potential as a possible therapeutic agent in neurodegenerative diseases involving oxidative stress.

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  • Molecular Neurodegeneration, 2009, London: BioMed Central

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  • Publication Title: Molecular Neurodegeneration
  • Volume: 4
  • Issue: 50
  • Peer Reviewed: Yes

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  • December 10, 2009

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  • Nov. 30, 2012, 9:15 a.m.

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  • March 6, 2014, 11 a.m.

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Duncan, Scott R.; Chapman, Kent D. & Koulen, Peter. The neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line, article, December 10, 2009; [London, United Kingdom]. (digital.library.unt.edu/ark:/67531/metadc122166/: accessed December 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.