Generalized anxiety modulates frontal and limbic activation in major depression Metadata

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Title

  • Main Title Generalized anxiety modulates frontal and limbic activation in major depression

Creator

  • Author: Schlund, Michael W.
    Creator Type: Personal
    Creator Info: University of North Texas; Johns Hopkins School of Medicine; Kennedy Krieger Institute
  • Author: Verduzco, Guillermo
    Creator Type: Personal
    Creator Info: Johns Hopkins School of Medicine
  • Author: Cataldo, Michael F.
    Creator Type: Personal
    Creator Info: Johns Hopkins School of Medicine; Kennedy Krieger Institute
  • Author: Hoehn-Saric, Rudolf
    Creator Type: Personal
    Creator Info: Johns Hopkins School of Medicine

Publisher

  • Name: BioMed Central Ltd.
    Place of Publication: [London, United Kingdom]

Date

  • Creation: 2012-02-09

Language

  • English

Description

  • Content Description: This article explores how generalized anxiety modulates frontal and limbic activation in major depression. The authors' findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context.
  • Physical Description: 5 p.

Subject

  • Keyword: generalized anxiety
  • Keyword: depression
  • Keyword: frontal
  • Keyword: limbic

Source

  • Journal: Behavioral and Brain Functions, 2012, London: BioMed Central Ltd.

Citation

  • Publication Title: Behavioral and Brain Functions
  • Volume: 8
  • Issue: 8
  • Peer Reviewed: True

Collection

  • Name: UNT Scholarly Works
    Code: UNTSW

Institution

  • Name: UNT College of Public Affairs and Community Service
    Code: UNTCPA

Rights

  • Rights Access: public
  • Rights License: by

Resource Type

  • Article

Format

  • Text

Identifier

  • DOI: 10.1186/1744-9081-8-8
  • Archival Resource Key: ark:/67531/metadc122164

Degree

  • Academic Department: Behavior Analysis

Note

  • Display Note: Abstract: Background: Anxiety is relatively common in depression and capable of modifying the severity and course of depression. Yet our understanding of how anxiety modulates frontal and limbic activation in depression is limited. Methods: We used functional magnetic resonance imaging and two emotional information processing tasks to examine frontal and limbic activation in ten patients with major depression and comorbid with preceding generalized anxiety (MDD/GAD) and ten non-depressed controls. Results: Consistent with prior studies on depression, MDD/GAD patients showed hypoactivation in medial and middle frontal regions, as well as in the anterior cingulate and insula. However, heightened anxiety in MDD/GAD patients was associated with increased activation in middle frontal regions and the insula and the effects varied with the type of emotional information presented. Conclusions: Our findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context. One implication of this finding is that divergent findings reported in the imaging literature on depression could reflect modulation of activation by anxiety level in response to different types of emotional information.