Generalized anxiety modulates frontal and limbic activation in major depression

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This article explores how generalized anxiety modulates frontal and limbic activation in major depression. The authors' findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context.

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Schlund, Michael W.; Verduzco, Guillermo; Cataldo, Michael F. & Hoehn-Saric, Rudolf February 9, 2012.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by the UNT College of Public Affairs and Community Service to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 979 times. More information about this article can be viewed below.

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This article explores how generalized anxiety modulates frontal and limbic activation in major depression. The authors' findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context.

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5 p.

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Abstract: Background: Anxiety is relatively common in depression and capable of modifying the severity and course of depression. Yet our understanding of how anxiety modulates frontal and limbic activation in depression is limited. Methods: We used functional magnetic resonance imaging and two emotional information processing tasks to examine frontal and limbic activation in ten patients with major depression and comorbid with preceding generalized anxiety (MDD/GAD) and ten non-depressed controls. Results: Consistent with prior studies on depression, MDD/GAD patients showed hypoactivation in medial and middle frontal regions, as well as in the anterior cingulate and insula. However, heightened anxiety in MDD/GAD patients was associated with increased activation in middle frontal regions and the insula and the effects varied with the type of emotional information presented. Conclusions: Our findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context. One implication of this finding is that divergent findings reported in the imaging literature on depression could reflect modulation of activation by anxiety level in response to different types of emotional information.

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  • Behavioral and Brain Functions, 2012, London: BioMed Central Ltd.

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  • Publication Title: Behavioral and Brain Functions
  • Volume: 8
  • Issue: 8
  • Peer Reviewed: Yes

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  • February 9, 2012

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  • Nov. 30, 2012, 9:15 a.m.

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  • June 24, 2014, 4:28 p.m.

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Schlund, Michael W.; Verduzco, Guillermo; Cataldo, Michael F. & Hoehn-Saric, Rudolf. Generalized anxiety modulates frontal and limbic activation in major depression, article, February 9, 2012; [London, United Kingdom]. (https://digital.library.unt.edu/ark:/67531/metadc122164/: accessed September 26, 2023), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Public Affairs and Community Service.

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