Poly(3-hydroxybutyrate) graft copolymer dense membranes for human mesenchymal stem cell growth

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This article discusses the preparation of thermal-remolded membrane scaffolds from poly(3-hydroxybutyrate) grafted with 2-amino-ehtyl methacrylate hydrochloride.

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8 p.

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González-Torres, Maykel; Sánchez-Sánchez, Roberto; Solís-Rosales, Silvia G.; Brostow, Witold, 1934-; Reyes-Cervantes, Eric; Gutiérrez-Uribe, Janet Alejandra et al. May 25, 2018.

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This article discusses the preparation of thermal-remolded membrane scaffolds from poly(3-hydroxybutyrate) grafted with 2-amino-ehtyl methacrylate hydrochloride.

Physical Description

8 p.

Notes

Abstract: Background: The use of novel materials as an artificial extracellular matrix for stem cell growth is a current strategy of increasing interest for regenerative medicine. Here, we prepare thermal remolded membrane scaffolds from poly(3-hydroxybutyrate) grafted with 2-amino-ethyl methacrylate hydrochloride. However, it is unclear whether these membranes are useful for tissue engineering.
Results: The mechanical properties, tribology, and morphology of the dense membranes were assessed. The results show that tensile strain at break and roughness of the compressed membrane decrease with increasing graft degree. Moreover, graft copolymer membranes showed lower resistance to scratching, greater degree of swelling and higher brittleness than un-grafted P(3HB) films. Thus, it effectively supports the growth of dermal fibroblast, as demonstrated by epifluorescence microscopy.
Conclusions: It is concluded that the developedmembrane can be properly used in is the restoration of skin tissue.

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  • Electric Journal of Biotechnology, 2018. Amsterdam, The Netherlands: Elsevier

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  • Publication Title: Electronic Journal of Biotechnology
  • Volume: 34
  • Page Start: 59
  • Page End: 66
  • Peer Reviewed: Yes

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UNT Scholarly Works

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  • May 25, 2018

Submitted Date

  • March 30, 2018

Accepted Date

  • May 23, 2018

Added to The UNT Digital Library

  • July 30, 2018, 12:01 p.m.

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González-Torres, Maykel; Sánchez-Sánchez, Roberto; Solís-Rosales, Silvia G.; Brostow, Witold, 1934-; Reyes-Cervantes, Eric; Gutiérrez-Uribe, Janet Alejandra et al. Poly(3-hydroxybutyrate) graft copolymer dense membranes for human mesenchymal stem cell growth, article, May 25, 2018; Amsterdam, The Netherlands. (digital.library.unt.edu/ark:/67531/metadc1213706/: accessed October 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Engineering.