Mixed ligand chelate therapy for plutonium and toxic metals from energy power production. Final report, April 15, 1977-October 14, 1980. [Mice]

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The results of experiments are summarized on the ability of combinations of chelating agents to modify the genotoxicity or tissue distributions. The mutagenicities of Cr and of chelating agents were determined. The metals described in the report are Pu(IV), Cd(II), Cr(III), and Cr(VI). Accurate measurements were made of the ability of CaNa/sub 2/EDTA, CaNa/sub 3/DTPA, and DMPS to reduce mortality in mice given doses (i.p.) of CdCl/sub 2/ well above the 100% lethal level. The efficacy in terms of the mmoles/kg needed to reduce the mortality was: DTPA > EDTA > DMPS. The combination of DTPA + DMPS proved most ... continued below

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Pages: 25

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Schubert, J. October 14, 1980.

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The results of experiments are summarized on the ability of combinations of chelating agents to modify the genotoxicity or tissue distributions. The mutagenicities of Cr and of chelating agents were determined. The metals described in the report are Pu(IV), Cd(II), Cr(III), and Cr(VI). Accurate measurements were made of the ability of CaNa/sub 2/EDTA, CaNa/sub 3/DTPA, and DMPS to reduce mortality in mice given doses (i.p.) of CdCl/sub 2/ well above the 100% lethal level. The efficacy in terms of the mmoles/kg needed to reduce the mortality was: DTPA > EDTA > DMPS. The combination of DTPA + DMPS proved most promising though little evidence for mixed complex formation was noted. Potentiometric titration studies the case of Pu(IV) a few combinations proved effective, but only when given shortly after Pu administration and then only in the liver but not the skeleton. It is recommended that metabolically stable chelating agents be used in combinations, especially for those combinations which may form very stable mixed ligand chelates.

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Pages: 25

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NTIS, PC A02/MF A01.

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  • Report No.: DOE/EV/04369-T1
  • Report No.: COO-4369-3
  • Grant Number: AS02-77EV04369
  • DOI: 10.2172/6394819 | External Link
  • Office of Scientific & Technical Information Report Number: 6394819
  • Archival Resource Key: ark:/67531/metadc1205798

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  • October 14, 1980

Added to The UNT Digital Library

  • July 5, 2018, 11:11 p.m.

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  • Sept. 4, 2018, 6:44 p.m.

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Schubert, J. Mixed ligand chelate therapy for plutonium and toxic metals from energy power production. Final report, April 15, 1977-October 14, 1980. [Mice], report, October 14, 1980; United States. (digital.library.unt.edu/ark:/67531/metadc1205798/: accessed December 14, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.