Cataract production in mice by heavy charged particles

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The cataractogenic effects of heavy charged particles have been evaluated in mice in relation to dose and ionization density (LET/sub infinity/). The study was undertaken due to the high potential for eye exposures to HZE particles among SPS personnel working in outer space. This has made it imperative that the relative biological effectiveness (RBE) in relation to LET/sub infinity/ for various particles be defined so that appropriate quality factors (Q) could be assigned for estimation of risk. Although mice and men differ in susceptibility to radiation-induced cataracts, the results from this project should assist in defining appropriate quality factors in ... continued below

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Pages: 46

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Ainsworth, E.H.; Jose, J.; Yang, V.V. & Barker, M.E. March 1, 1981.

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Description

The cataractogenic effects of heavy charged particles have been evaluated in mice in relation to dose and ionization density (LET/sub infinity/). The study was undertaken due to the high potential for eye exposures to HZE particles among SPS personnel working in outer space. This has made it imperative that the relative biological effectiveness (RBE) in relation to LET/sub infinity/ for various particles be defined so that appropriate quality factors (Q) could be assigned for estimation of risk. Although mice and men differ in susceptibility to radiation-induced cataracts, the results from this project should assist in defining appropriate quality factors in relation to LET/sub infinity/, particle mass, charge, or velocity. Evaluation of results indicated that : (1) low single doses (5 to 20 rad) of iron (/sup 56/Fe) or argon (/sup 40/Ar) particles are cataractogenic at 11 to 18 months after irradiation; (2) onset and density of the opacification are dose related; (3) cataract density (grade) at 9, 11, 13, and 16 months after irradiation shows partial LET/sub infinity/-dependence; and (4) the severity of cataracts is reduced significantly when 417 rad of /sup 60/Co gamma radiation is given in 24 weekly 17 rad fractions compared to giving this radiation as a single dose, but cataract severity is not reduced by fractionation of /sup 12/C doses over 24 weeks.

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Pages: 46

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NTIS, PC A03/MF A01.

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  • Report No.: LBL-12654
  • Grant Number: W-7405-ENG-48
  • DOI: 10.2172/6395022 | External Link
  • Office of Scientific & Technical Information Report Number: 6395022
  • Archival Resource Key: ark:/67531/metadc1203398

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • March 1, 1981

Added to The UNT Digital Library

  • July 5, 2018, 11:11 p.m.

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  • Oct. 30, 2018, 12:59 p.m.

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Ainsworth, E.H.; Jose, J.; Yang, V.V. & Barker, M.E. Cataract production in mice by heavy charged particles, report, March 1, 1981; California. (digital.library.unt.edu/ark:/67531/metadc1203398/: accessed November 14, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.