Metabolism and Distribution of Inhaled Plutonium in Rats

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Description

From abstract: "Several different techniques were used to introduce tracer quantities of plutonium into the lungs of rats. When aerosols were produced by atomizing aqueous solutions of the nitrates it was found that approximately 20 per cent of the dose was absorbed and deposited in the skelton [sic] with tetra-, hexa-, and trivalent plutonium. Thus with these compounds, the lungs represent a more dangerous portal of entry than either oral (0.05 per cent) or intramuscular (13 per cent) administration. Tetravalent Pu was eliminated most slowly from the lung, the average half-time during the first month being 15 days. But when … continued below

Physical Description

31 pages : illustrations.

Creation Information

Abrams, Richard; Siebert, H. C.; Potts, A. M.; Forker, L. L.; Greenberg, D.; Postel, A. et al. October 29, 1946.

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  • Main Title: Metabolism and Distribution of Inhaled Plutonium in Rats
  • Series Title: Atomic Energy Commission Reports
  • Series Title: MDDC (Series)
  • Added Title: Atomic Energy Commission Report MDDC-677
  • Added Title: Manhattan District Declassification Document MDDC 677

Description

From abstract: "Several different techniques were used to introduce tracer quantities of plutonium into the lungs of rats. When aerosols were produced by atomizing aqueous solutions of the nitrates it was found that approximately 20 per cent of the dose was absorbed and deposited in the skelton [sic] with tetra-, hexa-, and trivalent plutonium. Thus with these compounds, the lungs represent a more dangerous portal of entry than either oral (0.05 per cent) or intramuscular (13 per cent) administration. Tetravalent Pu was eliminated most slowly from the lung, the average half-time during the first month being 15 days. But when citrate was added to complex the Pu, over 70 per cent was eliminated within 1 day. This was accompanied by a deposition of over 30 per cent in the skelton [sic] and over 20 per cent in the liver. Presumably citrate breaks up the insoluble colloid in which Pu exists in the lungs. Complexing with cupferron which, unlike citrate, produces a "fat soluble" compound, greatly diminished the extent of absorption from the lungs. Plutonium oxide smokes which were produced at high temperatures were eliminated more slowly from the lungs (average half time of 30 days during the first month) and were deposited in the skeleton to a much lesser extent (6.2 per cent) than was the case with the nitrates."

Physical Description

31 pages : illustrations.

Notes

Digitized from microopaque cards.

"Metallurgical Laboratory."

"(With the technical assistance of Victoria Porter)."

"Report Received: October 29, 1946."

"Figures Received: November 8, 1946."

"Issued: January 13, 1947."

Includes bibliographical references (page 27).

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  • Report No.: MDDC-677
  • Grant Number: W-7401-eng-37
  • SuDoc Number: Y 3.At 7:22/MDDC-677
  • Accession or Local Control No: metadc1201823
  • Archival Resource Key: ark:/67531/metadc1201823

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Technical Report Archive and Image Library

The Technical Report Archive & Image Library (TRAIL) identifies, acquires, catalogs, digitizes and provides unrestricted access to U.S. government agency technical reports. The mission of TRAIL is to ensure preservation, discoverability, and persistent open access to government technical publications regardless of form or format.

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Imaged from microcard, these technical reports describe research performed for U.S. government agencies from the 1930s to the 1960s. The reports were provided by the Technical Report Archive and Image Library (TRAIL).

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  • October 29, 1946

Added to The UNT Digital Library

  • Aug. 27, 2019, 3:53 p.m.

Description Last Updated

  • April 1, 2020, 2:34 p.m.

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Abrams, Richard; Siebert, H. C.; Potts, A. M.; Forker, L. L.; Greenberg, D.; Postel, A. et al. Metabolism and Distribution of Inhaled Plutonium in Rats, report, October 29, 1946; Oak Ridge, Tennessee. (https://digital.library.unt.edu/ark:/67531/metadc1201823/: accessed June 15, 2025), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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