New prodrugs based on phospholipid-nucleoside conjugates Metadata

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  • Main Title New prodrugs based on phospholipid-nucleoside conjugates


  • Inventor: MacCoss, M.
    Creator Type: Personal


  • Assignee: United States. Department of Energy.
    Contributor Type: Organization
    Contributor Info: Patent Assignee: Dept. of Energy


  • Name: United States. Patent Office.
    Place of Publication: [Washington D.C.]


  • Creation: 1982-02-03


  • English


  • Content Description: A method is described for the preparation of defined, isomerically pure phospholipid-nucleoside conjugates as a prodrug in which the drug (araC) is attached to the phospholipid by a monophosphate linkage. Key intermediates in the process involve selective blocking and deblocking of the nucleoside derivative. These particular monophosphate-linked derivatives represent a new class of prodrug, which are useful by themselves or in combination with diphosphate linked derivatives. Several new compositions involving diphosphate linked derivatives are described in which the products are isomerically pure and having defined fatty acid chain lengths.
  • Physical Description: Pages: 22


  • Keyword: Nucleosides
  • Keyword: Esters
  • Keyword: Phosphates
  • Keyword: Organic Compounds
  • Keyword: Ribosides
  • Keyword: Drugs
  • STI Subject Categories: 59 Basic Biological Sciences
  • STI Subject Categories: 62 Radiology And Nuclear Medicine
  • Keyword: Phospholipids
  • STI Subject Categories: 550600 -- Medicine
  • Keyword: Phosphorus Compounds
  • Keyword: Lipids
  • Keyword: Chemical Bonds
  • Keyword: Chemical Preparation
  • Keyword: Antineoplastic Drugs
  • Keyword: Organic Phosphorus Compounds
  • Keyword: Synthesis 550200* -- Biochemistry
  • Keyword: Nucleotides
  • Keyword: Oxygen Compounds


  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI


  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Patent


  • Text


  • Other: DE83002391
  • Report No.: PATENTS-US-A345442
  • Grant Number: W-31-109-ENG-38
  • Office of Scientific & Technical Information Report Number: 6710935
  • Archival Resource Key: ark:/67531/metadc1192750


  • Display Note: NTIS, PC A02/MF A01.