Human semen assays for workplace monitoring. [Monitoring of hazardous materials by determining effects on semen of personnel]

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Decades of human semen studies have yielded compelling evidence that sperm can be used to access reproductive potential and diagnose pathology. With these studies as background, the small number of detailed semen studies of men exposed to physical and chemical agents point with optimism to the application of human semen assays as efficient, effective means to monitor for reproductive hazards in the workplace. Sperm are the most accessible of human gonadal tissue and provide a means of monitoring exposure induced changes in the human testes, changes which may result in infertility and increased frequencies of genetically abnormal gametes. The focus ... continued below

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Pages: 53

Creation Information

Wyrobek, A.J. & Gledhill, B.L. November 7, 1978.

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Description

Decades of human semen studies have yielded compelling evidence that sperm can be used to access reproductive potential and diagnose pathology. With these studies as background, the small number of detailed semen studies of men exposed to physical and chemical agents point with optimism to the application of human semen assays as efficient, effective means to monitor for reproductive hazards in the workplace. Sperm are the most accessible of human gonadal tissue and provide a means of monitoring exposure induced changes in the human testes, changes which may result in infertility and increased frequencies of genetically abnormal gametes. The focus on semen has precipitated the development of new sperm bioassays which use older conventional andrological methods (i.e., sperm counts, motility, and morphology) as well as recently developed high speed flow and scanning methods for automated cytological analyses. The status of these sperm assays for workplace surveillance is reviewed, procedures are suggested with examples of use, and their effectiveness is evaluated. The available mouse models of induced semen changes are briefly described and the importance of these models for evaluating the genetic implications of findings in human semen is discussed.

Physical Description

Pages: 53

Notes

Dep. NTIS, PC A04/MF A01.

Source

  • Workshop on methodology for assessing reproductive hazards in the workplace, Washington, DC, USA, Apr 1978

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  • Report No.: UCRL-81810
  • Report No.: CONF-7804106-1
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 6541266
  • Archival Resource Key: ark:/67531/metadc1182371

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • November 7, 1978

Added to The UNT Digital Library

  • July 3, 2018, 8:14 a.m.

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  • Sept. 24, 2018, 4:43 p.m.

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Wyrobek, A.J. & Gledhill, B.L. Human semen assays for workplace monitoring. [Monitoring of hazardous materials by determining effects on semen of personnel], article, November 7, 1978; United States. (digital.library.unt.edu/ark:/67531/metadc1182371/: accessed October 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.