Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin

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This article reports on the origin, evolution, and diversification of the iron-sulfur (2Fe-2S) binding motif CDGSH.

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12 p.

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Sengupta, Soham; Nechushtai, Rachel; Jennings, Patricia A.; Onuchic, José N.; Padilla, Pamela A.; Azad, Rajeev K. et al. March 19, 2018.

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This article reports on the origin, evolution, and diversification of the iron-sulfur (2Fe-2S) binding motif CDGSH.

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12 p.

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Abstract: The iron-sulfur (2Fe-2S) binding motif CDGSH appears in many important plant and animal proteins
that regulate iron and reactive oxygen metabolism. In human it is found in CISD1-3 proteins involved in
diabetes, obesity, cancer, aging, cardiovascular disease and neurodegeneration. Despite the important
biological role of the CDGSH domain, its origin, evolution and diversification, are largely unknown. Here,
we report that: (1) the CDGSH domain appeared early in evolution, perhaps linked to the heavy use of
iron-sulfur driven metabolism by early organisms; (2) a CISD3-like protein with two CDGSH domains on
the same polypeptide appears to represent the ancient archetype of CDGSH proteins; (3) the origin of the
human CISD3 protein is linked to the mitochondrial endosymbiotic event; (4) the CISD1/2 type proteins
that contain only one CDGSH domain, but function as homodimers, originated after the divergence
of bacteria and archaea/eukaryotes from their common ancestor; and (5) the human CISD1 and CISD2
proteins diverged about 650–720 million years ago, and CISD3 and CISD1/2 share their descent from an
ancestral CISD about 1–1.1 billion years ago. Our findings reveal that the CDGSH domain is ancient in its
origin and shed light on the complex evolutionary path of modern CDGSH proteins.

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  • Scientific Reports, 2018. London, UK: Nature Publishing Group

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  • Publication Title: Scientific Reports
  • Volume: 8
  • Pages: 12
  • Peer Reviewed: Yes

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UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

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  • November 28, 2017

Accepted Date

  • March 5, 2018

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  • March 19, 2018

Added to The UNT Digital Library

  • March 29, 2018, 10:10 p.m.

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  • Oct. 7, 2022, 3:14 p.m.

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Sengupta, Soham; Nechushtai, Rachel; Jennings, Patricia A.; Onuchic, José N.; Padilla, Pamela A.; Azad, Rajeev K. et al. Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin, article, March 19, 2018; London, United Kingdom. (https://digital.library.unt.edu/ark:/67531/metadc1115869/: accessed April 20, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Science.

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