Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells

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This article describes a facile one-step method to synthesize stable collodial gold nanoparticles (AuNPs) loaded with a combination of two anticancer therapeutics, -bleomycin and doxorubicin

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12 p.

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Farooq, Muhammad U.; Novosad, Valentyn; Rozhkova, Elena A.; Wali, Hussain; Ali, Asghar; Fateh, Ahmed A. et al. February 13, 2018.

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This article describes a facile one-step method to synthesize stable collodial gold nanoparticles (AuNPs) loaded with a combination of two anticancer therapeutics, -bleomycin and doxorubicin

Physical Description

12 p.

Notes

Abstract: Colloidal gold nanoparticles (AuNPs) are of interest as non-toxic carriers for drug delivery owing to
their advanced properties, such as extensive surface-to-volume ratio and possibilities for tailoring their
charge, hydrophilicity and functionality through surface chemistries. To date, various biocompatible
polymers have been used for surface decoration of AuNPs to enhance their stability, payloads capacity
and cellular uptake. This study describes a facile one-step method to synthesize stable AuNPs loaded
with combination of two anticancer therapeutics, -bleomycin and doxorubicin. Anticancer activities,
cytotoxicity, uptake and intracellular localization of the AuNPs were demonstrated in HeLa cells.
We show that the therapeutic efficacy of the nanohybrid drug was strongly enhanced by the active
targeting by the nanoscale delivery system to HeLa cells with a significant decrease of the halfmaximal
effective drug concentration, through blockage of HeLa cancer cell cycle. These results
provide rationale for further progress of AuNPs-assisted combination chemotherapy using two drugs
at optimized effective concentrations which act via different mechanisms thus decreasing possibilities
of development of the cancer drug resistance, reduction of systemic drug toxicity and improvement of
outcomes of chemotherapy.

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  • Scientific Reports, 2018. London, UK: Nature Publishing Group

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  • Publication Title: Scientific Reports
  • Volume: 8
  • Pages: 1-12
  • Peer Reviewed: Yes

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UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

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Submitted Date

  • September 20, 2017

Accepted Date

  • January 31, 2018

Creation Date

  • February 13, 2018

Added to The UNT Digital Library

  • Feb. 28, 2018, 6:41 p.m.

Description Last Updated

  • June 19, 2019, 7:43 p.m.

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Farooq, Muhammad U.; Novosad, Valentyn; Rozhkova, Elena A.; Wali, Hussain; Ali, Asghar; Fateh, Ahmed A. et al. Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells, article, February 13, 2018; London, United Kingdom. (https://digital.library.unt.edu/ark:/67531/metadc1114894/: accessed August 17, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT College of Arts and Sciences.