Evaluation of structure effects on the pharmacological behavior of radioiodinated phenylpentadecanoic acids

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For studying the pharmacokinetic behaviour of fatty acids with different chemical structures four STI-labelled compounds, i.e., the ortho and para STI-isomers of 15-phenylpentadecanoic acid (IPPA) and 3-methyl-15-phenylpentadecanoic acid were prepared and the organ distribution determined in mice. The results show a significant decrease of the maximal heart uptake for the two ortho compounds. Further, the hypothesis of a blocked metabolism as an effect of the US -methylation could not be confirmed. Both US -methylated compounds show a biexponential elimination behavior from the heart. 5 refs., 2 figs.

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Pages: 7

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Knapp, F.F. Jr.; Goodman, M.M.; Machulla, H.J.; Knust, E.J.; Kartje, M. & Vyska, K. January 1, 1986.

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Description

For studying the pharmacokinetic behaviour of fatty acids with different chemical structures four STI-labelled compounds, i.e., the ortho and para STI-isomers of 15-phenylpentadecanoic acid (IPPA) and 3-methyl-15-phenylpentadecanoic acid were prepared and the organ distribution determined in mice. The results show a significant decrease of the maximal heart uptake for the two ortho compounds. Further, the hypothesis of a blocked metabolism as an effect of the US -methylation could not be confirmed. Both US -methylated compounds show a biexponential elimination behavior from the heart. 5 refs., 2 figs.

Physical Description

Pages: 7

Notes

NTIS, PC A02/MF A01.

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  • International symposium on radioactive isotopes in clinical medicine and research, Badgastein, Austria, 13 Jan 1986

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  • Other: DE86005084
  • Report No.: CONF-860136-1
  • Grant Number: AC05-84OR21400
  • Office of Scientific & Technical Information Report Number: 6296957
  • Archival Resource Key: ark:/67531/metadc1114535

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  • January 1, 1986

Added to The UNT Digital Library

  • Feb. 22, 2018, 7:45 p.m.

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  • March 23, 2018, 2:16 p.m.

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Knapp, F.F. Jr.; Goodman, M.M.; Machulla, H.J.; Knust, E.J.; Kartje, M. & Vyska, K. Evaluation of structure effects on the pharmacological behavior of radioiodinated phenylpentadecanoic acids, article, January 1, 1986; United States. (digital.library.unt.edu/ark:/67531/metadc1114535/: accessed May 23, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.