Further studies on the genetic damage to bone marrow and other somatic effects following exposure to low level tritium

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This paper emphasizes results obtained over the last 3 years, supplementing information presented at the first /sup 3/H workshop. Sister chromtid exchange (SCE) measurements on mice maintained on 3.0 ..mu..Ci/ml of tritiated water (HTO) or receiving an equal depth dose /sup 137/Cs gamma exposure for 52 weeks have been completed. Small but significantly higher numbers of SCEs were found in animals receiving gamma exposures or maintained on HTO than in their controls. In animals removed from the HTO regimen after 27 weeks, the number of SCEs decreases with time, but did not return to control levels within the first 30 ... continued below

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Pages: 29

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Carsten, A.L.; Benz, R.D.; Commerford, S.L.; Hughes, W.; Ichimasa, Y.; Ikushima, T. et al. January 1, 1984.

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Description

This paper emphasizes results obtained over the last 3 years, supplementing information presented at the first /sup 3/H workshop. Sister chromtid exchange (SCE) measurements on mice maintained on 3.0 ..mu..Ci/ml of tritiated water (HTO) or receiving an equal depth dose /sup 137/Cs gamma exposure for 52 weeks have been completed. Small but significantly higher numbers of SCEs were found in animals receiving gamma exposures or maintained on HTO than in their controls. In animals removed from the HTO regimen after 27 weeks, the number of SCEs decreases with time, but did not return to control levels within the first 30 weeks. Comparative studies with the /sup 137/Cs exposures indicate an RBE not significantly different than 1.0. Mice were also maintained on 7.5, 15.0 and 30.0 ..mu..Ci/ml HTO for SCE studies. Results similar to those described for 3.0 ..mu..Ci/ml were found. Maintaining animals on a 0.15% saccharin solution is the most effective of those tested for increasing the animals' water intake and for enhancing excretion of /sup 3/H. The rate of disappearance of /sup 3/H from animals maintained chronically on HTO indicated a two phase /sup 3/H disappearance curve from hemoglobin. Single injections of HTO showed a brief delay in incorporation of /sup 3/H followed by a disappearance paralleling the slower phase of the chronic exposure curve, and indicating a RBC lifetime of approximately 40 days. 21 references, 7 figures, 1 table.

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Pages: 29

Notes

NTIS, PC A03/MF A01; 1.

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  • US/Japan workshop on tritium radiobiology and health physics, Tokyo, Japan, 29 Oct 1984

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  • Other: DE85005890
  • Report No.: BNL-35474
  • Report No.: CONF-8410171-4
  • Grant Number: AC02-76CH00016
  • Office of Scientific & Technical Information Report Number: 6099024
  • Archival Resource Key: ark:/67531/metadc1110363

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  • January 1, 1984

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  • Feb. 22, 2018, 7:45 p.m.

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  • March 28, 2018, 12:41 p.m.

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Carsten, A.L.; Benz, R.D.; Commerford, S.L.; Hughes, W.; Ichimasa, Y.; Ikushima, T. et al. Further studies on the genetic damage to bone marrow and other somatic effects following exposure to low level tritium, article, January 1, 1984; United States. (digital.library.unt.edu/ark:/67531/metadc1110363/: accessed April 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.