Measurements, in vivo, of parameters of the dopamine system

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This paper discusses methods of measuring important parameters of the dopamine system in the living animal by use of PET techniques. One primary concern is the density and binding affinity of post-synaptic neuroreceptors. A second concern is the activity of neurons. In vivo, this is generally related to the turnover of neurotransmitter and can also be related to the uptake of precursor compounds by the neurons. If the transmitter and neuroleptic compound compete for the same binding sites (on the receptor molecule) these two effects are interwoven and are not easily isolated. It appears that the movement of neuroleptic drugs ... continued below

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Pages: 30

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Friedman, A.M.; DeJesus, O.T.; Dinerstein, R. & Revenaugh, J. January 1, 1983.

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Description

This paper discusses methods of measuring important parameters of the dopamine system in the living animal by use of PET techniques. One primary concern is the density and binding affinity of post-synaptic neuroreceptors. A second concern is the activity of neurons. In vivo, this is generally related to the turnover of neurotransmitter and can also be related to the uptake of precursor compounds by the neurons. If the transmitter and neuroleptic compound compete for the same binding sites (on the receptor molecule) these two effects are interwoven and are not easily isolated. It appears that the movement of neuroleptic drugs from the brain is slow enough to allow equilibrium to be maintained between ligand and receptor, especially after some time for the initial washout and translocation in the brain. To test the consequences of equilibrium binding and the possible use of the model for measurement of receptor densities by emission tomography we have modified Clark's equilibrium model of ligand binding. In this note we will describe the solutions of the equations and some comparisons of the predictions of the model with data, as well as its application to tomographic measurements.

Physical Description

Pages: 30

Notes

NTIS, PC A03/MF A01.

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  • National Institute of Health workshop, Bethesda, MD, USA, 22 Jun 1983

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  • Other: DE83017964
  • Report No.: CONF-8306122-1
  • Grant Number: W-31-109-ENG-38
  • Office of Scientific & Technical Information Report Number: 5820876
  • Archival Resource Key: ark:/67531/metadc1104177

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • January 1, 1983

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  • Feb. 18, 2018, 3:59 p.m.

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  • April 19, 2018, 2:35 p.m.

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Friedman, A.M.; DeJesus, O.T.; Dinerstein, R. & Revenaugh, J. Measurements, in vivo, of parameters of the dopamine system, article, January 1, 1983; Illinois. (digital.library.unt.edu/ark:/67531/metadc1104177/: accessed September 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.