Nuclear medicine technology progress report for quarter ending June 30, 1979

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Diffusion chamber assay system studies on the relative cytotoxicity and target cell uptake of /sup 195m/Pt-labeled cis- and trans-dichlorodiammineplatinum(II) (cis- and trans-DDP) are reported. These two agents are excellent candidates for such studies since cis-DDP is an established potent antitumor agent while the trans-isomer exhibits little antitumor activity. The KB tumor cell population in chambers from the cis-DDP-treated animals decreased while the cell population in chambers from the trans-DDP-treated animals increased. Cytotoxicity data obtained in the study are similar to results from in vivo studies. The results of continuing studies with /sup 117m/Sn, /sup 123m/Te, /sup 75/Se, /sup 11/C, and ... continued below

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Pages: 26

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Knapp, F.F. Jr. August 1, 1979.

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Diffusion chamber assay system studies on the relative cytotoxicity and target cell uptake of /sup 195m/Pt-labeled cis- and trans-dichlorodiammineplatinum(II) (cis- and trans-DDP) are reported. These two agents are excellent candidates for such studies since cis-DDP is an established potent antitumor agent while the trans-isomer exhibits little antitumor activity. The KB tumor cell population in chambers from the cis-DDP-treated animals decreased while the cell population in chambers from the trans-DDP-treated animals increased. Cytotoxicity data obtained in the study are similar to results from in vivo studies. The results of continuing studies with /sup 117m/Sn, /sup 123m/Te, /sup 75/Se, /sup 11/C, and /sup 195m/Pt-labeled agents are also described. A series of five /sup 117m/Sn-labeled steroids containing a variety of structural modifications have been prepared. Future tissue distribution studies in rats will determine the potential usefulness of these agents for adrenal imaging applications. Based upon our studies with /sup 75/Se-labeled steroids (adrenal imaging) and fatty acids (myocardial imaging), the potential use of the /sup 73/Se-labeled agents for emission computerized axial tomographic applications is also discussed. Calculations of the estimated radiation dose to humans from two /sup 123m/Te-labeled steroids which suggest the potential clinical usefulness of these agents for adrenal visualization have been completed. Patient studies have continued with /sup 11/C-aminocyclobutanecarboxylic acid (ACBC) and /sup 11/C-tryptophan. Continuing studies with /sup 195m/Pt-labeled antitumor agents are also reported. (ERB)

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Pages: 26

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Dep. NTIS, PC A03/MF A01.

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  • Report No.: ORNL/TM-6958
  • Grant Number: W-7405-ENG-26
  • DOI: 10.2172/5975530 | External Link
  • Office of Scientific & Technical Information Report Number: 5975530
  • Archival Resource Key: ark:/67531/metadc1100949

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  • August 1, 1979

Added to The UNT Digital Library

  • Feb. 18, 2018, 3:59 p.m.

Description Last Updated

  • May 15, 2018, 5:53 p.m.

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Knapp, F.F. Jr. Nuclear medicine technology progress report for quarter ending June 30, 1979, report, August 1, 1979; Tennessee. (digital.library.unt.edu/ark:/67531/metadc1100949/: accessed October 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.