Relationship between unscheduled DNA synthesis and mutation induction in male mice

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Unscheduled DNA synthesis (UDS) induced in the germ cells of male mice by chemical and physical agents can be studied in vivo by making use of the timing of spermatogenesis and spermiogenesis. In meiotic and post-meiotic germ-cell stages UDS occurs from leptotene through mid-spermatid stages but is not detected in later stages. No consistent correlation has been seen between the occurrence of UDS in the germ cells and reduced dominant-lethal frequencies or reduced specific-locus mutation frequencies. It is suggested that the UDS observed in the germ cells may be principally involved in the removal of DNA lesions which, if left, ... continued below

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Pages: 28

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Sega, G. A. January 1, 1979.

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Unscheduled DNA synthesis (UDS) induced in the germ cells of male mice by chemical and physical agents can be studied in vivo by making use of the timing of spermatogenesis and spermiogenesis. In meiotic and post-meiotic germ-cell stages UDS occurs from leptotene through mid-spermatid stages but is not detected in later stages. No consistent correlation has been seen between the occurrence of UDS in the germ cells and reduced dominant-lethal frequencies or reduced specific-locus mutation frequencies. It is suggested that the UDS observed in the germ cells may be principally involved in the removal of DNA lesions which, if left, could give rise to subtle genetic damage that current mammalian genetic tests may not be able to detect. Characterization of mouse stocks with reduced UDS capability in their germ cells plus the development of biochemical genetic markers that can measure single amino acid substitutions will likely be necessary before the relationship between UDS in mammalian germ cells and repair of genetic damage can be clearly established.

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Pages: 28

Notes

Dep. NTIS, PC A03/MF A01.

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  • Conference on DNA repair and mutagenesis in bacteria, Atlanta, GA, USA, 25 Jun 1979

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  • Report No.: CONF-790676-8
  • Grant Number: W-7405-ENG-26
  • Office of Scientific & Technical Information Report Number: 5875770
  • Archival Resource Key: ark:/67531/metadc1100586

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • January 1, 1979

Added to The UNT Digital Library

  • Feb. 18, 2018, 3:59 p.m.

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  • May 18, 2018, 12:36 p.m.

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Sega, G. A. Relationship between unscheduled DNA synthesis and mutation induction in male mice, article, January 1, 1979; Tennessee. (digital.library.unt.edu/ark:/67531/metadc1100586/: accessed July 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.