Alterations in the metabolism of benzo(a)pyrene in syrian hamster embryo (SHE) cells pretreated with phenolic antioxidants

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Inhibition of chemical- or raddiation-induced neoplasia has been observed in animals whose diets were supplemented with antioxidants commonly used as food additives. Inhibition of the carcinogenicity of benzo(a)pyrene (BaP) or of 7,12-dimenthylbenz(a)anthracene (DMBA) - in rats has been achieved by the addition of the phenolic antioxidants butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) to the diet. Our data suggest that in SHE cells antioxidants inhibit the overall metabolism of BaP to its various oxidized moieties including 7,8-diol- and 7,8,9,10-tetrol-BaP. A plausible explanation for our results with SHE cells is that the antioxidants interact directly with AHH, thus inhibiting AHH metabolic ... continued below

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Pages: 16

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Strniste, G.F.; Okinaka, R.T. & Chen, D.J. January 1, 1983.

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Inhibition of chemical- or raddiation-induced neoplasia has been observed in animals whose diets were supplemented with antioxidants commonly used as food additives. Inhibition of the carcinogenicity of benzo(a)pyrene (BaP) or of 7,12-dimenthylbenz(a)anthracene (DMBA) - in rats has been achieved by the addition of the phenolic antioxidants butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) to the diet. Our data suggest that in SHE cells antioxidants inhibit the overall metabolism of BaP to its various oxidized moieties including 7,8-diol- and 7,8,9,10-tetrol-BaP. A plausible explanation for our results with SHE cells is that the antioxidants interact directly with AHH, thus inhibiting AHH metabolic capacity. From analysis of nuclear material from SHE cells (+- antioxidants) incubated for 36 hours with BaP at 1 ..mu..g/ml, it is calculated that 4.6, 2.4 and 2.9 pmol BaP are bound to the DNA isolated from 10/sup 7/ nuclei of control, BHA-(20 ..mu..g/ml) and p-MP-(10 ..mu..g/ml) treated cultures, respectively.

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Pages: 16

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NTIS, PC A02/MF A01.

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  • 8. international symposium on polynuclear aromatic hydrocarbons, Columbus, OH, USA, 26 Oct 1983

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  • Other: DE84001723
  • Report No.: LA-UR-83-3093
  • Report No.: CONF-8310179-2
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 5578308
  • Archival Resource Key: ark:/67531/metadc1093782

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Office of Scientific & Technical Information Technical Reports

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  • January 1, 1983

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  • Feb. 10, 2018, 10:06 p.m.

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  • May 11, 2018, 11:54 a.m.

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Strniste, G.F.; Okinaka, R.T. & Chen, D.J. Alterations in the metabolism of benzo(a)pyrene in syrian hamster embryo (SHE) cells pretreated with phenolic antioxidants, article, January 1, 1983; New Mexico. (digital.library.unt.edu/ark:/67531/metadc1093782/: accessed October 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.