Treatment planning with ion beams

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Ions have higher linear energy transfer (LET) near the end of their range and lower LET away from the end of their range. Mixing radiations of different LET complicates treatment planning because radiation kills cells in two statistically independent ways. In some cases, cells are killed by a single-particle, which causes a linear decrease in log survival at low dosage. When the linear decrease is subtracted from the log survival curve, the remaining curve has zero slope at zero dosage. This curve is the log survival curve for cells that are killed only by two or more particles. These two ... continued below

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Pages: 4

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Foss, M.H. January 1, 1985.

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Description

Ions have higher linear energy transfer (LET) near the end of their range and lower LET away from the end of their range. Mixing radiations of different LET complicates treatment planning because radiation kills cells in two statistically independent ways. In some cases, cells are killed by a single-particle, which causes a linear decrease in log survival at low dosage. When the linear decrease is subtracted from the log survival curve, the remaining curve has zero slope at zero dosage. This curve is the log survival curve for cells that are killed only by two or more particles. These two mechanisms are statistically independent. To calculate survival, these two kinds of doses must be accumulated separately. The effect of each accumulated dosage must be read from its survival curve, and the logarithms of the two effects added to get the log survival. Treatment plans for doses of protons, He/sup 3/ ions, and He/sup 4/ ions suggest that these ions will be useful therapeutic modalities.

Physical Description

Pages: 4

Notes

NTIS, PC A02/MF A01; 1.

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  • Particle accelerator conference, Vancouver, Canada, 13 May 1985

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  • Other: DE85012661
  • Report No.: LA-UR-85-1616
  • Report No.: CONF-850504-54
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 5584239
  • Archival Resource Key: ark:/67531/metadc1093554

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • January 1, 1985

Added to The UNT Digital Library

  • Feb. 10, 2018, 10:06 p.m.

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  • May 25, 2018, 5:37 p.m.

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Foss, M.H. Treatment planning with ion beams, article, January 1, 1985; New Mexico. (digital.library.unt.edu/ark:/67531/metadc1093554/: accessed July 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.