Production of tungsten-188 and osmium-194 in a nuclear reactor for new clinical generators

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Rhenium-188 and iridium-194 are potential candidates for radioimmunotherapy with monoclonal antibodies directed against tumor-associated antigens. Both nuclei are short-lived and decay by high energy {Beta}{minus} emission. In addition, both nuclei emit {gamma}-rays with energy suitable for imaging. An important characteristics is availability of {sup 188}Re and {sup 194}Ir from decay of reactor-produced parents ({sup 188}W and {sup 194}Os, respectively) in convenient generator systems. The {sup 188}W and {sup 194}Os are produced by double neutron capture of {sup 186}W and {sup 192}Os, respectively. The large scale production yields of {sup 188}W in several nuclear reactors will be presented. We also report ... continued below

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Mirzadeh, S.; Knapp, F.F. Jr. & Callahan, A.P. January 1, 1991.

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Rhenium-188 and iridium-194 are potential candidates for radioimmunotherapy with monoclonal antibodies directed against tumor-associated antigens. Both nuclei are short-lived and decay by high energy {Beta}{minus} emission. In addition, both nuclei emit {gamma}-rays with energy suitable for imaging. An important characteristics is availability of {sup 188}Re and {sup 194}Ir from decay of reactor-produced parents ({sup 188}W and {sup 194}Os, respectively) in convenient generator systems. The {sup 188}W and {sup 194}Os are produced by double neutron capture of {sup 186}W and {sup 192}Os, respectively. The large scale production yields of {sup 188}W in several nuclear reactors will be presented. We also report a new management for the cross-section of {sup 193}Os(n,{gamma}){sup 194}Os reaction and discuss the feasibility of producing sufficient quantities of {sup 194}Os. 17 refs., 1 fig., 2 tabs.

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Pages: (8 p)

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OSTI; NTIS; INIS; GPO Dep.

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  • International conference on nuclear data for science and technology, Juelich (Germany, F.R.), 13-17 May 1991

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  • Other: DE91014544
  • Report No.: CONF-910503-27-Extd.Abst.
  • Grant Number: AC05-84OR21400
  • Office of Scientific & Technical Information Report Number: 5525933
  • Archival Resource Key: ark:/67531/metadc1093355

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • January 1, 1991

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  • Feb. 10, 2018, 10:06 p.m.

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  • Feb. 23, 2018, 6:58 p.m.

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Mirzadeh, S.; Knapp, F.F. Jr. & Callahan, A.P. Production of tungsten-188 and osmium-194 in a nuclear reactor for new clinical generators, article, January 1, 1991; Tennessee. (digital.library.unt.edu/ark:/67531/metadc1093355/: accessed November 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.