Establishment of a bioassay system for cancer risk assessment in energy technology Metadata

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  • Main Title Establishment of a bioassay system for cancer risk assessment in energy technology


  • Author: Ts'o, P.O.P.
    Creator Type: Personal
  • Author: Bruce, S.A.
    Creator Type: Personal
  • Author: Brown, A. (eds.)
    Creator Type: Personal


  • Name: Johns Hopkins Univ., Baltimore, MD (USA). School of Hygiene and Public Health
    Place of Publication: United States


  • Creation: 1983-09-01


  • English


  • Content Description: Separate abstracts were prepared for 20 papers in this report. For several years the Department of Energy (DOE), Office of Health and Environmental Research (OHER), has supported a research program aimed at developing new experimental approaches for the improvement of cancer risk assessments. The central issue is to overcome the organizational, species and other barriers that make it difficult to extrapolate laboratory-based data to predict risk to man. Most of the participants at the meeting are involved in research aimed at understanding the mechanism(s) of chemical carcinogenesis. Complex mixtures of chemicals are associated with many energy technologies. DOE's initial program emphasis focused on semi-applied research aimed at quantitative evaluation of carcinogenic activity of complex materials. Since much progress has been made in DOE integrated technology-specific chemical-biological characterization studies, the number and kinds of chemicals of concern has been reduced to a relatively few well-defined classes. Although the classes of compounds seem to be unique to some of the synfuel technologies, they are quite similar to compounds of general interest, for example, poly-nuclear aromatic hydrocarbons. Special emphasis was placed on molecular and cellular dosimetry as one of the key requirements for quantitative comparison of effects at the cell level in vivo and in vitro. Although it is relatively easy to measure cell, tissue, organ and whole organism doses associated with radiation exposures, we are just learning how to do this for chemical agents. Several methods have been developed in the past several years which can be used.
  • Physical Description: Pages: 196


  • Keyword: Shale Oil
  • Keyword: Fuels
  • Keyword: Organic Compounds
  • Keyword: Document Types
  • Keyword: Biological Variability
  • Keyword: Liquids
  • Keyword: Carcinogenesis
  • Keyword: Other Organic Compounds
  • STI Subject Categories: 59 Basic Biological Sciences
  • STI Subject Categories: 550200 -- Biochemistry
  • Keyword: Fossil Fuels
  • Keyword: Coal Liquids
  • Keyword: Mineral Oils
  • Keyword: Leading Abstract
  • Keyword: Abstracts
  • Keyword: Oils
  • Keyword: Carcinogens
  • STI Subject Categories: 63 Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.
  • Keyword: Meetings
  • STI Subject Categories: 550700 -- Microbiology
  • Keyword: Risk Assessment
  • Keyword: Cell Cultures
  • Keyword: Energy Sources
  • Keyword: Biological Models
  • Keyword: Fluids
  • Keyword: Bioassay
  • Keyword: Pathogenesis 560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)


  • Conference: Conference on establishment of a bioassay system for cancer risk assessment in energy technology, Baltimore, MD, USA, 3 May 1982


  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI


  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Article


  • Text


  • Other: DE84001127
  • Report No.: CONF-8205230-Summ.
  • Grant Number: FG02-82ER60057
  • Office of Scientific & Technical Information Report Number: 5514008
  • Archival Resource Key: ark:/67531/metadc1093075


  • Display Note: NTIS, PC A09/MF A01; 1.