Repair of DNA treated with. gamma. -irradiation and chemical carcinogens. Progress report, March 15, 1979-March 15, 1980

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The identification and purification of 3-methyladenine glycosylase from the cell nuclei of rat liver was completed. The characterization of 7-methylguanine N-glycosylase activity in E. coli is currently under investigation. Alkylated DNA in chromatin structures as a substrate for 3-methyladenine N-glycosylase is discussed. An enzyme from E. coli and mammalian tissue active on 2,6-diamino-4-hydroxy-5-N-methyldormamido-pyrimide is isolated and characterized. Studies are proceeding on the correlation of x-ray sensitivity with removal of alkylated bases from DNA in x-ray sensitive and x-ray resistant lines of lymphoma cells. The reaction of ..beta..-propiolactone with derivatives of adenine and with DNA is discussed.

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Pages: 5

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Goldthwait, D.A. January 1, 1980.

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Description

The identification and purification of 3-methyladenine glycosylase from the cell nuclei of rat liver was completed. The characterization of 7-methylguanine N-glycosylase activity in E. coli is currently under investigation. Alkylated DNA in chromatin structures as a substrate for 3-methyladenine N-glycosylase is discussed. An enzyme from E. coli and mammalian tissue active on 2,6-diamino-4-hydroxy-5-N-methyldormamido-pyrimide is isolated and characterized. Studies are proceeding on the correlation of x-ray sensitivity with removal of alkylated bases from DNA in x-ray sensitive and x-ray resistant lines of lymphoma cells. The reaction of ..beta..-propiolactone with derivatives of adenine and with DNA is discussed.

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Pages: 5

Notes

Dep. NTIS, PC A02/MF A01.

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  • Report No.: COO-2725-05
  • Grant Number: EY-76-S-02-2725
  • DOI: 10.2172/5520036 | External Link
  • Office of Scientific & Technical Information Report Number: 5520036
  • Archival Resource Key: ark:/67531/metadc1092653

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  • January 1, 1980

Added to The UNT Digital Library

  • Feb. 10, 2018, 10:06 p.m.

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  • April 13, 2018, 11:37 a.m.

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Goldthwait, D.A. Repair of DNA treated with. gamma. -irradiation and chemical carcinogens. Progress report, March 15, 1979-March 15, 1980, report, January 1, 1980; United States. (digital.library.unt.edu/ark:/67531/metadc1092653/: accessed October 16, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.