Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method Page: 4
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a yellow color in solution containing the steroid, phenyl-
hydrazine and sulfuric acid#
lost workers (2, 5, 6, 7) agree that the liver is the
principal sit© of metabolism of the adrenocorticolds. How-
ever, Bernstein (1), working with allotransplantation of
adrenal glands to the spleen and mesentery of rata, concluded
that the liver plays no essential destructive role in the
metabolism of the adrenal cortical steroids# Liver slices,
homogenates and cell fractions have been studied to determine
the ability of each to metabolize corticosteroids. Brown (2)
reported a greater loss of hydrocortisone from media after
incubation with liver slices than with homogenates or cell
Hori (4), in a study of the enzyme systems of X-irradiated
mouse liver, reported some enzymes increased and others de-
creased after whole body irradiation. Ska Iks (9) found that
after poisoning the liver, rats were more sensitive to irradi-
ation. Though muoh work is being done to study the effects
of X-irradiation on various systems, relatively little work
using X-irradiation as a stress agent has been reported• It
•was the purpose of this study to determine the metabolism of
hydrocortisone by X—irradiat ed rat liver slices and to attempt
to relate the findings to the General Adaptation Syndrome.
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Pryor, Nan Webb. Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method, thesis, August 1959; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc108062/m1/9/: accessed December 14, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .