Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method Page: 3
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have a highly reactive hydroxy 1 group at carbon 21. They also
have a keto grouping at carbon 3 which may in some instances
be reduced to a hydroxy1 group with alpha-beta isomerism.
Hydrocortisone, which belongs to this group, is a gluco-
corticoid. Its formula isi
Jo Ci 0
The gluco-cortlcoids are particularly important in tissue re-
pair since they are capable of mobilizing glucose and amino
acids in the body. In this respect they are necessary for the
animal's ability to survive the initial damage Incurred during
the alarm stage of stress.
The hydrocortisone used in this study was readily avail-
able from the laboratories of Merck, Sharp© and Dohme. The
method of ana lysis used in the present investigation was the
Porter-Silber chromagen met hod which is speoific for 17, 21-
dihydroxy-20-ket©steroids. It Is based on the appearance of
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Pryor, Nan Webb. Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method, thesis, August 1959; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc108062/m1/8/: accessed February 17, 2019), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .