Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method Page: 31
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M.V-&W siloes taken from rats at various time intervals
following whole body X-lrradlation ^ere tea ted for their
ability to metabolize hydrocortisone from « Krobs-Ringer
solution, fhe animala received total dosages of 426r, 856r
and 1712r X-lrradlatian. The livers were reaoved four boors,
twenty~f&m hours and two weeks after Irradia felon, fb«
method used to analyze the steroid was the Porter-Sliber
chroma gen method# . .
4 decrease In metabolism of hydrocortisone was found
at each dosage level and time interval tested# the moat
significant decrease (42 per cent) occurred in liver*
removed twenty-four hoars after th® aninals received # dosage
of 1712r X*irradlatlon«
It was ooneladed that whole body oxpoaure of rata to
X~irradiatlon causes a deoreaae la the Metabolism of hydro-
oortlaone by rat liver slices. The results were discussed
m the basis -of asatoaioal liver daaag© due to irradiation
and m the possible saturation of liver enzymes by increased
asiotmt of circulating corticosteroids#
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Pryor, Nan Webb. Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method, thesis, August 1959; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc108062/m1/36/: accessed March 21, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; .