Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method Page: 27

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poisoning, water intoxication and sot?oaure to cold, having
little or a® advantage over sdrenaleet oolsed rats in with-
standing th® first two stresses# fhis imps instant in function
mm correlated with reduction in aass of docketing adreno-
cortical tissue and presumably decrease in circulating Iswl
of corticosteroids, resulting from delayed vegsneva felon #f
the-Efdrradlated transplants# s . •
the observed decrease in metabolism of hydrocortisone
in the present study may be explained in the following three
ways« fhe first and most probable explanation is that lrrad-
iation bringa about anatomical and physiological damage to
the liver* Secondly, due to an increase to circulating cortico-
steroids brought about by irradiation, the tniyaes of the
liver (normal or irradiated) involved with corticosteroid
®t b®ll«i may boo ©me saturated* A third possibility Bight
be that adding the steroid to already saturated erutymes la
damaged liver ©ells would result in a decrease in the meta-
bolism of tip steroid.
Wwm tha results of the present investigation, one night
mete the following significant conclusion In regard to the
Stress Syndrome in general* It has been shown that X-irrsdiatlem
brings about sn increase in the amount of circulating cortico-
steroids $m the body * ffhe results indicate that these steroids
may persist in the body unchanged for a longer period of time
because of the inability of a damaged liver to metabolize•them*
the. resultant sustained level of corticosteroid concentration

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Pryor, Nan Webb. Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method, thesis, August 1959; Denton, Texas. ( accessed March 24, 2019), University of North Texas Libraries, Digital Library,; .

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