Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method Page: 24
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caused an increase in metabolism of hydroeortisone# Ala©
rats bearing tumor# metabolized hydrocortisone at an increased
A study of fell® effect of X-irradiation m ensyme systems
of til© souse liver and® by Ho*i (5) showed m $mrmm of such
enzymes at oats las#, tricarboxylic sold cycle and oxidative
phoapbwrylefelon♦ A® increase to ATPase, 5-meXeotldss© and
desoacynuc lease was noted. Haass e£ a|.. (8) mi® a study of
the effects of 4000a? to 20,0003? Irradiation m rat lif 3f ex-
tracts and reported no effect m enzyse activity waa observed.
fates at jyu (11) to reporting the affect of triiodo-
thyronine on ring A reduction of cortisone by the liver,
stated that the administration of this hormone Increases the
total hepatic capacity for ylfee# reduction #f ring A of
cortisone, and ttayro-parat hy roldeetoay decreases thla capacity.
It waa concluded that theae alterative in thyroid state in-
fluence hectic reduction of corticoaterolds in several wayss
CD the total amount of delta4-steroid hydrogenases in the
lives? may be altered, both by changes in liver sis® and by
changea in amount of enzyme per gram of liver j and (g) the
activity per gram of Uw can also be altered through vari-
ations in coenzyme CfJPHH) availability. It was suggested by
these workers that the rate of ring A reduction of cortico-
steroids fey liver determines the rate ©f ACTH aeoretlon in
unstressed animals* Other workers (4) described an mzyme
system which degrades the 17, 21-d ihydroxy~20~keterne side-ohain
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Pryor, Nan Webb. Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method, thesis, August 1959; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc108062/m1/29/: accessed March 21, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; .