Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method Page: 23
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The data from IMs investigation indicate that X-irradiation
brings a beat a decrease in tbs metabolism of hydrocortisone by
liver slices from rats* Inhibit less sppeara to be doss dependent*
fhe time of the wmmml of tbs liver following irradiation
appears to be important also# A decrease in metabolism was
found at all doaage lew la msed and at each time internal
Brosm (3) in his study of metabolism of hydrocortisone
by rat liver alicet, reported a rate of hydrocortiaone meta-
bolism by control liver slices amounting to 71 tig. per 100 mg •
per hour* This was almost tviae the amount reported for con-
trol rata Sa the present study*- The difference in rates of
metabolism may be explained by variation# in mothers and equip-
ment* Brown added WO ug. of hydrocortlsene to flasks containing
Si© mg of tiaaue« la the present study the amount of hydro-
cortisone aided to each flssk was 600 ug*, and each flask
contained 500 mg. of tiaaue* A aetabolio stoking machine waa
used by Brown instead of the improvised shaker uaed in this
study* Brown reported a 32 per cent decrease in metabolism of
hydrocortisone following hypophysectomy of rats* Thyroid*1*
ectomized rats ahowed a 24 per cent decrease in hydrocortiaone
metabolism* Pre treatment of rats with cortisone and thyroxine
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Pryor, Nan Webb. Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method, thesis, August 1959; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc108062/m1/28/: accessed December 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .