Problems and prospects in future applications of stable isotopes in the life sciences and medicine

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In the last decade, there has been a resurgence of interest in the use of stable isotopes of carbon, oxygen, and nitrogen in the life sciences and medicine fueled by the increased availability of the isotopes and isotopically labeled compounds and of instruments for their detection. Accelerated development of /sup 13/C, /sup 15/N, and /sup 17/ /sup 18/O can be expected in the future for studies of drug bioavailability, nutrition and body protein economy, viability of organs for transplant, and for non-invasive tests of metabolic diseases and dysfunctions. These accelerated developments depend on continued improvements in nmr and ms instrumentation ... continued below

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Pages: 13

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Matwiyoff, N.A.; Unkefer, C.J. & Walker, T.E. January 1, 1982.

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Description

In the last decade, there has been a resurgence of interest in the use of stable isotopes of carbon, oxygen, and nitrogen in the life sciences and medicine fueled by the increased availability of the isotopes and isotopically labeled compounds and of instruments for their detection. Accelerated development of /sup 13/C, /sup 15/N, and /sup 17/ /sup 18/O can be expected in the future for studies of drug bioavailability, nutrition and body protein economy, viability of organs for transplant, and for non-invasive tests of metabolic diseases and dysfunctions. These accelerated developments depend on continued improvements in nmr and ms instrumentation and in methods for the synthesis of isotopically labeled compounds. The main part of this paper explores the possibilities of biosynthesis for the selective enrichment of natural products, especially amino acids, with /sup 13/C.

Physical Description

Pages: 13

Notes

NTIS, PC A02/MF A01.

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  • International symposium on the synthesis and applications of isotopically labeled compounds, Kansas City, MO, USA, 6 Jun 1982

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  • Other: DE82017358
  • Report No.: LA-UR-82-1860
  • Report No.: CONF-820666-2
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 5244931
  • Archival Resource Key: ark:/67531/metadc1074473

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Office of Scientific & Technical Information Technical Reports

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  • January 1, 1982

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  • Feb. 4, 2018, 10:51 a.m.

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  • May 30, 2018, 12:21 p.m.

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Matwiyoff, N.A.; Unkefer, C.J. & Walker, T.E. Problems and prospects in future applications of stable isotopes in the life sciences and medicine, article, January 1, 1982; New Mexico. (digital.library.unt.edu/ark:/67531/metadc1074473/: accessed October 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.