Development and application of photosensitive device systems to studies of biological and organic materials Page: 2 of 27
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I) INTRODUCTION & SUMMARY
This report describes progress as of the third year of a 3-year DoE grant DE-FG-02-
87ER60522 for the fiscal period 1/1/92 to 12/31/92. Two earlier annual progress reports
(DOE/ER/60522-4 & -5) covered the first two years of the 3-year grant cycle. Because
this is the last year of a 3-year grant cycle, this report will summarize progress over the
entire 3-year period. The overall goals of the grant are to develop novel instrumentation
and techniques for the performance of biological and materials research, and especially
for the development of x-ray detectors suitable for use at storage ring sources. Research
progress has been excellent and the overall goals, as well as most of the specific goals have
been successfully met.
The research is well guided by the philosophy that useful instrumentation develop-
ment and basic biostructural and materials research are inseparably coupled and proceed
effectively when the instrumentation development is driven by specific needs of basic re-
search problems. To insure this coupling, the Princeton Biophysics group has avoided the
division of the group into “instrumentation” and “applications” specialists; rather, each
group member is simultaneously involved in both development of instrumentation and the
application of the instrumentation developed to basic research problems being worked on
by that individual.
Because this is the last progress report in a 3-year grant cycle, it is useful to very
briefly summarize the high points of the results over the entire three-year period. The
period 1/1/90 thru the present has been one of fruition for the development of CCD-based
area x-ray detectors, ancillary instrumentation and biomaterials research. By now, the
Princeton Biophysics group has overseen the assembly, testing, and application of over a
half dozen CCD-based detectors. The process has involved detailed evaluations of all the
components (hardware and software) of these devices. Several of the detectors are now
well out of the development stage and are routinely used to perform biomaterials research.
Large scale development for dedicated storage ring application is now underway.
At the same time, significant biomaterials research has been performed with the detec-
tors and ancillary instrumentation developed under this grant. Of particular significance
are studies on the effects of high pressures on biomembranes and experiments on lipid-
With respect to the training goals of the grant, two graduate students have been
trained through to a Ph.D., four undergraduates have graduated with senior theses per-
formed on the apparatus, and two post-docs are part way through their training.
Specific accomplishments of the grant include:
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Gruner, S.M. & Reynolds, G.T. Development and application of photosensitive device systems to studies of biological and organic materials, report, May 15, 1992; United States. (https://digital.library.unt.edu/ark:/67531/metadc1072386/m1/2/: accessed April 23, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.