Biophysical and biomathematical adventures in radiobiology

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Highlights of my biophysical and biomathematical adventures in radiobiology is presented. Early adventures involved developing state-vector models'' for specific harmful effects (cell killing, life shortening) of exposure to radiation. More recent adventures led to developing hazard-function models'' for predicting biological effects (e.g., cell killing, mutations, tumor induction) of combined exposure to different toxicants. Hazard-function models were also developed for predicting harm to man from exposure to large radiation doses. Major conclusions derived from the modeling adventures are as follows: (1) synergistic effects of different genotoxic agents should not occur at low doses; (2) for exposure of the lung or bone ... continued below

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Pages: (30 p)

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Scott, B.R. January 1, 1991.

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Description

Highlights of my biophysical and biomathematical adventures in radiobiology is presented. Early adventures involved developing state-vector models'' for specific harmful effects (cell killing, life shortening) of exposure to radiation. More recent adventures led to developing hazard-function models'' for predicting biological effects (e.g., cell killing, mutations, tumor induction) of combined exposure to different toxicants. Hazard-function models were also developed for predicting harm to man from exposure to large radiation doses. Major conclusions derived from the modeling adventures are as follows: (1) synergistic effects of different genotoxic agents should not occur at low doses; (2) for exposure of the lung or bone marrow to large doses of photon radiation, low rates of exposure should be better tolerated than high rates; and (3) for some types of radiation (e.g., alpha particles and fission neutrons), moderate doses delivered at a low rate may be more harmful than the same dose given at a high rate. 53 refs., 7 figs.

Physical Description

Pages: (30 p)

Notes

OSTI; NTIS; INIS; GPO Dep.

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  • 5. annual Southern University College of Science symposium on versatility and wonders or physics, Baton Rouge, LA (United States), Mar 1991

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  • Other: DE91017484
  • Report No.: CONF-9103198-1
  • Grant Number: AC04-76EV01013
  • DOI: 10.1016/0006-291X(91)90446-E | External Link
  • Office of Scientific & Technical Information Report Number: 5448711
  • Archival Resource Key: ark:/67531/metadc1071823

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • January 1, 1991

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  • Feb. 4, 2018, 10:51 a.m.

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  • March 1, 2018, 8:10 p.m.

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Scott, B.R. Biophysical and biomathematical adventures in radiobiology, article, January 1, 1991; United States. (digital.library.unt.edu/ark:/67531/metadc1071823/: accessed October 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.