6-Acetyldihydrohomopterin and sepiapterin affect some GTP cyclohydrolase I's and not others Metadata

Metadata describes a digital item, providing (if known) such information as creator, publisher, contents, size, relationship to other resources, and more. Metadata may also contain "preservation" components that help us to maintain the integrity of digital files over time.

Title

  • Main Title 6-Acetyldihydrohomopterin and sepiapterin affect some GTP cyclohydrolase I's and not others

Creator

  • Author: Jacobson, K.B.
    Creator Type: Personal
  • Author: Manos, R.E.
    Creator Type: Personal

Publisher

  • Name: Oak Ridge National Lab., TN (USA)
    Place of Publication: United States
  • Name: Tennessee Univ., Oak Ridge (USA). Graduate School of Biomedical Sciences
    Place of Publication: United States

Date

  • Creation: 1988-01-01

Language

  • English

Description

  • Content Description: The first enzyme in pteridine biosynthesis, GTP cyclohydrolase I, is a likely site for regulation of pteridine biosynthesis to occur. GTP cyclohydrolase I responds to hormonal treatment and is found altered in a variety of mice with genetically based neurological and immunological disorders. Genetic loci can greatly modify the activity of GTP cyclohydrolase: Punch mutant in Drosophila hph-1 in mouse and atypical phenylketonuria in human. This report examines the ability of Ahp and sepiapterin to alter the activity of GTP cyclohydrolase I from mouse liver, rat liver and Drosophila head. 20 refs., 2 tabs.
  • Physical Description: Pages: 10

Subject

  • Keyword: Cyclases
  • Keyword: Separation Processes 550201* -- Biochemistry-- Tracer Techniques
  • Keyword: Organic Compounds
  • Keyword: Enzymes
  • STI Subject Categories: 59 Basic Biological Sciences
  • Keyword: Tracer Techniques
  • Keyword: Aromatics
  • Keyword: Carbon 14 Compounds
  • Keyword: Progress Report
  • Keyword: Pteridines
  • Keyword: Document Types
  • Keyword: Organic Nitrogen Compounds
  • Keyword: Lyases
  • Keyword: Fractionation
  • Keyword: Heterocyclic Compounds
  • Keyword: Isotope Applications
  • Keyword: Labelled Compounds
  • Keyword: Azaarenes

Source

  • Conference: Annual international pteridine workshop, Snowbird, UT, USA, 13 Mar 1988

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Article

Format

  • Text

Identifier

  • Other: DE88006778
  • Report No.: CONF-880361-1
  • Grant Number: AC05-84OR21400
  • Office of Scientific & Technical Information Report Number: 5357984
  • Archival Resource Key: ark:/67531/metadc1070958

Note

  • Display Note: NTIS, PC A02/MF A01.