6-Acetyldihydrohomopterin and sepiapterin affect some GTP cyclohydrolase I's and not others Metadata

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  • Main Title 6-Acetyldihydrohomopterin and sepiapterin affect some GTP cyclohydrolase I's and not others


  • Author: Jacobson, K.B.
    Creator Type: Personal
  • Author: Manos, R.E.
    Creator Type: Personal


  • Name: Oak Ridge National Lab., TN (USA)
    Place of Publication: United States
  • Name: Tennessee Univ., Oak Ridge (USA). Graduate School of Biomedical Sciences
    Place of Publication: United States


  • Creation: 1988-01-01


  • English


  • Content Description: The first enzyme in pteridine biosynthesis, GTP cyclohydrolase I, is a likely site for regulation of pteridine biosynthesis to occur. GTP cyclohydrolase I responds to hormonal treatment and is found altered in a variety of mice with genetically based neurological and immunological disorders. Genetic loci can greatly modify the activity of GTP cyclohydrolase: Punch mutant in Drosophila hph-1 in mouse and atypical phenylketonuria in human. This report examines the ability of Ahp and sepiapterin to alter the activity of GTP cyclohydrolase I from mouse liver, rat liver and Drosophila head. 20 refs., 2 tabs.
  • Physical Description: Pages: 10


  • Keyword: Cyclases
  • Keyword: Separation Processes 550201* -- Biochemistry-- Tracer Techniques
  • Keyword: Organic Compounds
  • Keyword: Enzymes
  • STI Subject Categories: 59 Basic Biological Sciences
  • Keyword: Tracer Techniques
  • Keyword: Aromatics
  • Keyword: Carbon 14 Compounds
  • Keyword: Progress Report
  • Keyword: Pteridines
  • Keyword: Document Types
  • Keyword: Organic Nitrogen Compounds
  • Keyword: Lyases
  • Keyword: Fractionation
  • Keyword: Heterocyclic Compounds
  • Keyword: Isotope Applications
  • Keyword: Labelled Compounds
  • Keyword: Azaarenes


  • Conference: Annual international pteridine workshop, Snowbird, UT, USA, 13 Mar 1988


  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI


  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Article


  • Text


  • Other: DE88006778
  • Report No.: CONF-880361-1
  • Grant Number: AC05-84OR21400
  • Office of Scientific & Technical Information Report Number: 5357984
  • Archival Resource Key: ark:/67531/metadc1070958


  • Display Note: NTIS, PC A02/MF A01.