Radiation-induced mesotheliomas in rats

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Mesotheliomas have been reported in rats that inhaled plutonium, but these tumors have not been extensively studied. To investigate a possible role for inhaled radionuclides in the induction of mesotheliomas, four life-span studies conducted at the Inhalation Toxicology Research Institute are reviewed. A total of 3076 F344 rats were exposed by inhalation to aerosols of {sup 239}PuO{sub 2}, mixed uranium-plutonium oxide, or {sup 144}CeO{sub 2}. Results showed that a low incidence of pleural mesotheliomas was induced by either alpha- or beta-emitting radionuclides deposited and retained in the lung. Chronic alpha irradiation was more effective per unit dose in producing mesotheliomas ... continued below

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Pages: (14 p)

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Hahn, F.F.; Haley, P.J.; Hubbs, A.F.; Hoover, M.D. & Lundgren, D.L. January 1, 1990.

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Mesotheliomas have been reported in rats that inhaled plutonium, but these tumors have not been extensively studied. To investigate a possible role for inhaled radionuclides in the induction of mesotheliomas, four life-span studies conducted at the Inhalation Toxicology Research Institute are reviewed. A total of 3076 F344 rats were exposed by inhalation to aerosols of {sup 239}PuO{sub 2}, mixed uranium-plutonium oxide, or {sup 144}CeO{sub 2}. Results showed that a low incidence of pleural mesotheliomas was induced by either alpha- or beta-emitting radionuclides deposited and retained in the lung. Chronic alpha irradiation was more effective per unit dose in producing mesotheliomas than chronic beta irradiation of the lung by a factor of 15. 7 refs., 1 tab., 7 figs. (MHB)

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Pages: (14 p)

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OSTI; NTIS; INIS; GPO Dep.

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  • International workshop on mechanisms in fiber carcinogenesis, Albuquerque, NM (United States), 22-25 Oct 1990

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  • Other: DE91017485
  • Report No.: CONF-9010406-1
  • Grant Number: AC04-76EV01013
  • Office of Scientific & Technical Information Report Number: 5448166
  • Archival Resource Key: ark:/67531/metadc1070364

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  • January 1, 1990

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  • Feb. 4, 2018, 10:51 a.m.

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  • March 7, 2018, 7:06 p.m.

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Hahn, F.F.; Haley, P.J.; Hubbs, A.F.; Hoover, M.D. & Lundgren, D.L. Radiation-induced mesotheliomas in rats, article, January 1, 1990; United States. (digital.library.unt.edu/ark:/67531/metadc1070364/: accessed May 25, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.