Particle deposition in human and canine tracheobronchial casts

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The aim of this work is to measure deposition patterns and efficiencies of aerosol particles within realistic, single-pathway physical models of the tracheobronchial airways of humans and experimental animals over a range of particle sizes for a variety of respiratory modes and rates. This will provide data needed to assess the dose to the bronchial epithelium from inhaled radon progeny. In prior grant years an empirical expression for diffusional deposition efficiency of particles in the upper airways was obtained based on experimental data collected in central airway casts. The work also provided new quantitative data of airflow distribution in a ... continued below

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Pages: (11 p)

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Cohen, B.S. November 15, 1991.

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Description

The aim of this work is to measure deposition patterns and efficiencies of aerosol particles within realistic, single-pathway physical models of the tracheobronchial airways of humans and experimental animals over a range of particle sizes for a variety of respiratory modes and rates. This will provide data needed to assess the dose to the bronchial epithelium from inhaled radon progeny. In prior grant years an empirical expression for diffusional deposition efficiency of particles in the upper airways was obtained based on experimental data collected in central airway casts. The work also provided new quantitative data of airflow distribution in a realistic central airway cast for two species for both steady and pulsatile inspiratory flow and for expiratory flow. Theoretical studies were then extended based on a developing flow model. We concluded that although the developing flow model is a better predictor of the data than assumption of parabolic flow, the predicted deposition is significantly lower than that predicted by our best fit equation. In the current year the experimental results were evaluated in terms of the parametric solution of the convective diffusion equation.

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Pages: (11 p)

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OSTI; NTIS; GPO Dep.

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  • Other: DE92013475
  • Report No.: DOE/ER/60592-7
  • Grant Number: FG02-87ER60592
  • DOI: 10.2172/5309552 | External Link
  • Office of Scientific & Technical Information Report Number: 5309552
  • Archival Resource Key: ark:/67531/metadc1068631

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Creation Date

  • November 15, 1991

Added to The UNT Digital Library

  • Feb. 4, 2018, 10:51 a.m.

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  • March 2, 2018, 8 p.m.

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Cohen, B.S. Particle deposition in human and canine tracheobronchial casts, report, November 15, 1991; United States. (digital.library.unt.edu/ark:/67531/metadc1068631/: accessed September 26, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.