Synthesis and in-vivo detection of boronated compounds for use in BNCT

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Description

The primary objective of the DOE program at The University of Tennessee Graduate School of Medicine is the development of effective molecular medicine for use in neutron-capture therapy (NCT). The research focuses primarily on the preparation of new boron-rich NCT agents and the technology to detect them in-vivo. The detection technology involves the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring NCT agents in-vivo. The synthetic program is directed toward the design of novel boron NCT (BNCT) agents which are targeted to the cell nucleus and gadolinium liposomes targeted to the liver. The ... continued below

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Pages: (21 p)

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Kabalka, G.W. January 1, 1992.

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Description

The primary objective of the DOE program at The University of Tennessee Graduate School of Medicine is the development of effective molecular medicine for use in neutron-capture therapy (NCT). The research focuses primarily on the preparation of new boron-rich NCT agents and the technology to detect them in-vivo. The detection technology involves the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring NCT agents in-vivo. The synthetic program is directed toward the design of novel boron NCT (BNCT) agents which are targeted to the cell nucleus and gadolinium liposomes targeted to the liver. The UT-DOE program is unique in that it has access to both state-of-the-art whole-body and microscopy MRI instruments.

Physical Description

Pages: (21 p)

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OSTI; NTIS; GPO Dep.

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  • Other: DE92013583
  • Report No.: DOE/ER/60892-3
  • Grant Number: FG05-89ER60892
  • Office of Scientific & Technical Information Report Number: 5376288
  • Archival Resource Key: ark:/67531/metadc1066913

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 1, 1992

Added to The UNT Digital Library

  • Feb. 4, 2018, 10:51 a.m.

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  • March 6, 2018, 7:33 p.m.

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Kabalka, G.W. Synthesis and in-vivo detection of boronated compounds for use in BNCT, report, January 1, 1992; United States. (digital.library.unt.edu/ark:/67531/metadc1066913/: accessed April 26, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.