Inhalation developmental toxicology studies: Teratology study of n-hexane in rats: Final report Metadata

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Title

  • Main Title Inhalation developmental toxicology studies: Teratology study of n-hexane in rats: Final report

Creator

  • Author: Mast, T.J.
    Creator Type: Personal

Publisher

  • Name: Pacific Northwest Laboratory
    Place of Publication: Richland, Washington

Date

  • Creation: 1987-12-01

Language

  • English

Description

  • Content Description: The straight chain hydrocarbon, n-hexane, is a volatile, ubiquitous solvent used in industrial, academic, and smaller commercial environments. The significant opportunity for women of child-bearing age to be exposed to this chemical prompted the undertaking of a study to assess the developmental toxicity of n-hexane in an animal model. Timed-pregnant (30 animals per group) and virgin (10 animals per group) Sprague-Dawley rats were exposed to 0 (filtered air), 200, 1000, and 5000 ppM n-hexane (99.9% purity) vapor in inhalation chambers for 20 h/day for a period of 14 consecutive days. Sperm-positive females were exposed for 6 to 19 days of gestation (dg) and virgins were exposed concurrently for 14 consecutive days. The day of sperm detection was designated as 0 dg for mated females. Adult female body weights were monitored prior to, throughout the exposure period, and at sacrifice. Uterine, placental, and fetal body weights were obtained for gravid females at sacrifice. Implants were enumerated and their status recorded as live fetus, early or late resorption, or dead. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 16 refs., 3 figs., 7 tabs.
  • Physical Description: Pages: 208

Subject

  • Keyword: Mammals
  • Keyword: Organic Compounds
  • Keyword: Progress Report
  • Keyword: Document Types
  • Keyword: Time Dependence
  • Keyword: Volatile Matter
  • Keyword: Hexane
  • Keyword: Intake
  • Keyword: Inhalation
  • Keyword: Animals
  • Keyword: Pathological Changes
  • Keyword: Matter
  • Keyword: Toxicity
  • Keyword: Congenital Malformations
  • Keyword: Hydrocarbons
  • Keyword: Malformations
  • Keyword: Rats
  • Keyword: Fetuses
  • STI Subject Categories: 63 Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.
  • Keyword: Teratogenesis
  • Keyword: Prenatal Exposure
  • Keyword: Vertebrates 560300* -- Chemicals Metabolism & Toxicology
  • Keyword: Sex Dependence
  • Keyword: Rodents
  • Keyword: Alkanes

Source

  • Other Information: Portions of this document are illegible in microfiche products

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report

Format

  • Text

Identifier

  • Other: DE88006812
  • Report No.: PNL-6453
  • Grant Number: AC06-76RL01830
  • DOI: 10.2172/5440289
  • Office of Scientific & Technical Information Report Number: 5440289
  • Archival Resource Key: ark:/67531/metadc1065233

Note

  • Display Note: NTIS, PC A10/MF A01; 1.