Quantitative mammalian cell genetic toxicology: study of the cytotoxicity and mutagenicity of 70 individual environmental agents related to energy technologies and 3 subfractions of a crude synthetic oil in the CHO/HGPRT system. [Hamsters] Page: 4 of 40
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As science and technology advance, an extraordinary quantity of
natural and synthetic chemicals is introduced continuously into our
environment. Through the conventional animal tests, some of these
environmental chemicals have been found to be either highly toxic,
mutagenic, carcinogenic, or teratogenic. Epidemiological studies have
shown that among these harmful chemicals, a few also exhibit such
detrimental effects in the human population. Because of the high
cost and long duration required for the animal experiments, such
tests have been confined to only a very small fraction of these
environmental agents. Thus, the biological effects of the great
majority of these chemicals, including ingredients of our daily foods
and drugs, remain either incompletely tested or unknown.
During the past few years, evidence has accumulated that a high
percentage (80-90%) of human cancer is linked to exposure to industrial
and environmental chemicals identifiable as carcinogens (23, 44).
Since the expense of animal tests preclude their routine use to
identify environmental.carcinogens, many short-term assays have been
developed as initial carcinogen screening tests. Studies of mutagenesis
and DNA-repair in microorganisms, especially Salmonella typhimurium
and Escherichia coli, have established that approximately 90% of
chemical carcinogens cause mutation induction or DNA damage in these
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Hsie, A. W.; Neill, J. P. & San Sebastian, J. R. Quantitative mammalian cell genetic toxicology: study of the cytotoxicity and mutagenicity of 70 individual environmental agents related to energy technologies and 3 subfractions of a crude synthetic oil in the CHO/HGPRT system. [Hamsters], report, January 1, 1978; Tennessee. (https://digital.library.unt.edu/ark:/67531/metadc1061464/m1/4/: accessed March 18, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.