Problems and solutions in the estimation of genetic risks from radiation and chemicals

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Extensive investigations with mice on the effects of various physical and biological factors, such as dose rate, sex and cell stage, on radiation-induced mutation have provided an evaluation of the genetics hazards of radiation in man. The mutational results obtained in both sexes with progressive lowering of the radiation dose rate have permitted estimation of the mutation frequency expected under the low-level radiation conditions of most human exposure. Supplementing the studies on mutation frequency are investigations on the phenotypic effects of mutations in mice, particularly anatomical disorders of the skeleton, which allow an estimation of the degree of human handicap ... continued below

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Pages: 20

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Russell, W.L. January 1, 1980.

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Description

Extensive investigations with mice on the effects of various physical and biological factors, such as dose rate, sex and cell stage, on radiation-induced mutation have provided an evaluation of the genetics hazards of radiation in man. The mutational results obtained in both sexes with progressive lowering of the radiation dose rate have permitted estimation of the mutation frequency expected under the low-level radiation conditions of most human exposure. Supplementing the studies on mutation frequency are investigations on the phenotypic effects of mutations in mice, particularly anatomical disorders of the skeleton, which allow an estimation of the degree of human handicap associated with the occurrence of parallel defects in man. Estimation of the genetic risk from chemical mutagens is much more difficult, and the research is much less advanced. Results on transmitted mutations in mice indicate a poor correlation with mutation induction in non-mammalian organisms.

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Pages: 20

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NTIS, PC A02/MF A01.

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  • 13. Rochester international conference on environmental toxicity--measurement of risks, Rochester, NY, USA, 2 Jun 1980

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  • Report No.: CONF-800601-3
  • Grant Number: W-7405-ENG-26
  • Office of Scientific & Technical Information Report Number: 5025098
  • Archival Resource Key: ark:/67531/metadc1059339

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Office of Scientific & Technical Information Technical Reports

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  • January 1, 1980

Added to The UNT Digital Library

  • Jan. 22, 2018, 7:23 a.m.

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  • Feb. 1, 2018, 3:20 p.m.

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Russell, W.L. Problems and solutions in the estimation of genetic risks from radiation and chemicals, article, January 1, 1980; Tennessee. (digital.library.unt.edu/ark:/67531/metadc1059339/: accessed September 25, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.