Conceptual strategy for design, implementation, and validation of a biomarker-based biomonitoring capability

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This document describes a strategy for defining specific objectives for biomarker studies and for designing and implementing a biomonitoring study that focuses on these objectives. In researching this subject, it became clear to the authors that the subject of biomarkers created a great deal of interest among scientists and regulators but that general acceptance of biomarkers as a tool for environmental protection was hampered by lack of a clear notion of how to develop and apply this approach. We intend this document to be a user's guide'' that lays out a logical scheme for applying biomarkers in environmental monitoring. In ... continued below

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Pages: (85 p)

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McCarthy, J.F.; Halbrook, R.S. & Shugart, L.R. December 1, 1991.

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Description

This document describes a strategy for defining specific objectives for biomarker studies and for designing and implementing a biomonitoring study that focuses on these objectives. In researching this subject, it became clear to the authors that the subject of biomarkers created a great deal of interest among scientists and regulators but that general acceptance of biomarkers as a tool for environmental protection was hampered by lack of a clear notion of how to develop and apply this approach. We intend this document to be a user's guide'' that lays out a logical scheme for applying biomarkers in environmental monitoring. In addition, laboratory and field research components needed to develop and validate fundamental understanding and interpretation of biomarker responses are also described, as is a strategy for evolution of a biomarker-based biomonitoring capability. The document is divided into sections intended to lead the reader to an understanding of how biomarkers can be developed and applied.

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Pages: (85 p)

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OSTI; NTIS; GPO Dep.

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  • Other Information: Environmental Sciences Division Publication No. 3702

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  • Other: DE92014937
  • Report No.: ORNL/TM-11783
  • Grant Number: AC05-84OR21400
  • DOI: 10.2172/5202322 | External Link
  • Office of Scientific & Technical Information Report Number: 5202322
  • Archival Resource Key: ark:/67531/metadc1058581

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  • December 1, 1991

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  • Jan. 22, 2018, 7:23 a.m.

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  • Feb. 1, 2018, 6:16 p.m.

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McCarthy, J.F.; Halbrook, R.S. & Shugart, L.R. Conceptual strategy for design, implementation, and validation of a biomarker-based biomonitoring capability, report, December 1, 1991; Tennessee. (digital.library.unt.edu/ark:/67531/metadc1058581/: accessed February 23, 2019), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.