Late biological effects of ionizing radiation as influenced by dose, dose rate, age at exposure, and genetic sensitivity to neoplastic transformation. [Gamma radiation, mice]

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A most comprehensive investigation is in progress at the Los Alamos Scientific Laboratory to study the late biological effects of whole-body exposure to gamma irradiation as they may be influenced by total dose, dose rate, age at exposure, and genetic background. Strain C57B1/6J mice of four age groups (newborn, 2, 6, and 15 months) were given five doses (20, 60, 180, 540, and 1620 rad) of gamma rays, with each dose being delivered at six dose rates (0.7, 2.1, 6.3, 18.9, 56.7 rad/day and 25 rad/min). Forty to sixty mice were used in each of the approximately 110 dose/dose-rate and ... continued below

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Pages: 11

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Spalding, J.F.; Prine, J.R. & Tietjen, G.L. January 1, 1978.

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Description

A most comprehensive investigation is in progress at the Los Alamos Scientific Laboratory to study the late biological effects of whole-body exposure to gamma irradiation as they may be influenced by total dose, dose rate, age at exposure, and genetic background. Strain C57B1/6J mice of four age groups (newborn, 2, 6, and 15 months) were given five doses (20, 60, 180, 540, and 1620 rad) of gamma rays, with each dose being delivered at six dose rates (0.7, 2.1, 6.3, 18.9, 56.7 rad/day and 25 rad/min). Forty to sixty mice were used in each of the approximately 110 dose/dose-rate and age combinations. The study was done in two replications with an equal number of mice per replication. Strain RF/J mice were used in a companion study to investigate the influence of genetic background on the type and magnitude of effect. Results of the first and second replications of the 15-month-old age group and data on the influence of genetic background on biological response have been completed, and the results show no significant life shortening within the dose and dose-rate range used.

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Pages: 11

Notes

Dep. NTIS, PC A02/MF A01.

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  • Symposium on late biological effects of ionizing radiation, Vienna, Austria, 13 Mar 1978

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  • Report No.: LA-UR-78-681
  • Report No.: CONF-780306-4
  • Report No.: IAEA-SM-224/201
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 5043221
  • Archival Resource Key: ark:/67531/metadc1057877

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 1, 1978

Added to The UNT Digital Library

  • Jan. 22, 2018, 7:23 a.m.

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  • Feb. 2, 2018, 2:40 p.m.

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Spalding, J.F.; Prine, J.R. & Tietjen, G.L. Late biological effects of ionizing radiation as influenced by dose, dose rate, age at exposure, and genetic sensitivity to neoplastic transformation. [Gamma radiation, mice], article, January 1, 1978; New Mexico. (digital.library.unt.edu/ark:/67531/metadc1057877/: accessed July 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.