Role of drosophila in chemical mutagenesis testing

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An important question facing our society is the impact of numerous chemical insults on the health of man and his environment. Faced with a staggering array of chemicals and enormous testing costs, only a few chemicals can be tested for possible carcinogenic effects. Recent results with the Salmonella/mammalian microsome mutagenesis bioassay system demonstrate a striking correlation between carcinogenicity and mutagenicity of many chemical compounds and offer the possibility that mutagenesis assay systems can provide a quick identification of potential carcinogens. Results from microbial assays can serve as a guideline for further mutagenesis testing as well as identify those compounds requiring ... continued below

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Pages: 20

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Nix, C.E. & Brewen, B. January 1, 1978.

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Description

An important question facing our society is the impact of numerous chemical insults on the health of man and his environment. Faced with a staggering array of chemicals and enormous testing costs, only a few chemicals can be tested for possible carcinogenic effects. Recent results with the Salmonella/mammalian microsome mutagenesis bioassay system demonstrate a striking correlation between carcinogenicity and mutagenicity of many chemical compounds and offer the possibility that mutagenesis assay systems can provide a quick identification of potential carcinogens. Results from microbial assays can serve as a guideline for further mutagenesis testing as well as identify those compounds requiring more extensive analysis in mammalian systems. Reliance on the results from a single mutagenic assay system is rather risky. It would be preferable to use a battery of tests (the tier approach) which would include the rapid microbial assays as well as mammalian systems. Also the use of Drosophila as a bridge between the microbial and mammalian assays has many desirable features which are discussed.

Physical Description

Pages: 20

Notes

Dep. NTIS, PC A02/MF A01.

Source

  • Symposium on application of short-term bioassays in the fractionation and analysis of complex environmental mixtures, Williamsburg, VA, USA, 21 Feb 1978

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  • Report No.: CONF-780227-1
  • Grant Number: W-7405-ENG-26
  • Office of Scientific & Technical Information Report Number: 5133960
  • Archival Resource Key: ark:/67531/metadc1057755

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • January 1, 1978

Added to The UNT Digital Library

  • Jan. 22, 2018, 7:23 a.m.

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  • Feb. 1, 2018, 6:13 p.m.

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Nix, C.E. & Brewen, B. Role of drosophila in chemical mutagenesis testing, article, January 1, 1978; Tennessee. (digital.library.unt.edu/ark:/67531/metadc1057755/: accessed November 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.