Microdistribution of lead in bone: A new approach

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A knowledge of the microdistribution of lead in bone is important in order to understand the mechanisms for accumulation and release of lead. The availability of the synchrotron x-ray microscope for sensitive measurements of bone content and distribution of lead provides a valuable tool which, when combined with kinetic, balance, and tissue measurements, can lead to better evaluation of lead toxicity. It may also provide the basis for the development of a suitable model of how lead behaves in the human body. An outline of an experimental protocol for exploitation of the x-ray microscope is given, along with synchrotron x-ray ... continued below

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Pages: (17 p)

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Jones, K.W. (Brookhaven National Lab., Upton, NY (United States)); Bockman, R.S. (Cornell Univ., New York, NY (United States). Medical Coll.) & Bronner, F. (Connecticut Univ. Health Center, Farmington, CT (United States)) January 1, 1991.

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Description

A knowledge of the microdistribution of lead in bone is important in order to understand the mechanisms for accumulation and release of lead. The availability of the synchrotron x-ray microscope for sensitive measurements of bone content and distribution of lead provides a valuable tool which, when combined with kinetic, balance, and tissue measurements, can lead to better evaluation of lead toxicity. It may also provide the basis for the development of a suitable model of how lead behaves in the human body. An outline of an experimental protocol for exploitation of the x-ray microscope is given, along with synchrotron x-ray microscope measurements of the distribution of gallium in rat bone that demonstrate the feasibility of the experimental approach.

Physical Description

Pages: (17 p)

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OSTI; NTIS; GPO Dep.

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  • Workshop on lead: metabolism and bone deposition, Upton, NY (United States), 10-12 Apr 1991

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  • Other: DE92013036
  • Report No.: BNL-47370
  • Report No.: CONF-9104363--1
  • Grant Number: AC02-76CH00016
  • Office of Scientific & Technical Information Report Number: 5158582
  • Archival Resource Key: ark:/67531/metadc1057719

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  • January 1, 1991

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  • Jan. 22, 2018, 7:23 a.m.

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  • Feb. 5, 2018, 1:30 p.m.

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Jones, K.W. (Brookhaven National Lab., Upton, NY (United States)); Bockman, R.S. (Cornell Univ., New York, NY (United States). Medical Coll.) & Bronner, F. (Connecticut Univ. Health Center, Farmington, CT (United States)). Microdistribution of lead in bone: A new approach, article, January 1, 1991; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc1057719/: accessed May 23, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.