Exploratory research on mutagenic activity of coal-related materials

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The following samples were found to be mutagenic for strains TA1538, TA98 and TA100 Salmonella typhimurium: ETTM-10, ETTM-11, ETTM-15, ETTM-16, and ETTM-17. ETTM-13 was marginally mutagenic for TA1537. ETTM-14 was slightly mutagenic for TA1537, TA1538, and TA98. Mutagenicity by all samples was demonstrated only in the presence of hepatic enzyme extracts (S9) which provided metabolic activation. ETTM-11 was shown to be the most mutagenic sample assayed thus far; specific activity was 2.79 x 10/sup 4/ TA98 revertants/mg sample. Fractionation by serial extractions with increasingly polar organic solvents was done at least 2 x with ETTM-10, ETTM-11, ETTM-15, ETTM-16 and ETTM-17. ... continued below

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Pages: 42

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Warshawsky, D. & Schoeny, R. S. January 1, 1980.

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Description

The following samples were found to be mutagenic for strains TA1538, TA98 and TA100 Salmonella typhimurium: ETTM-10, ETTM-11, ETTM-15, ETTM-16, and ETTM-17. ETTM-13 was marginally mutagenic for TA1537. ETTM-14 was slightly mutagenic for TA1537, TA1538, and TA98. Mutagenicity by all samples was demonstrated only in the presence of hepatic enzyme extracts (S9) which provided metabolic activation. ETTM-11 was shown to be the most mutagenic sample assayed thus far; specific activity was 2.79 x 10/sup 4/ TA98 revertants/mg sample. Fractionation by serial extractions with increasingly polar organic solvents was done at least 2 x with ETTM-10, ETTM-11, ETTM-15, ETTM-16 and ETTM-17. For some samples highly mutagenic fractions were observed.

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Pages: 42

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NTIS, PC A03/MF A01.

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  • Report No.: DOE/ET/00222-4
  • Grant Number: AS22-78ET00222
  • DOI: 10.2172/5179078 | External Link
  • Office of Scientific & Technical Information Report Number: 5179078
  • Archival Resource Key: ark:/67531/metadc1057040

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 1, 1980

Added to The UNT Digital Library

  • Jan. 22, 2018, 7:23 a.m.

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  • Jan. 25, 2018, 12:48 p.m.

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Warshawsky, D. & Schoeny, R. S. Exploratory research on mutagenic activity of coal-related materials, report, January 1, 1980; United States. (digital.library.unt.edu/ark:/67531/metadc1057040/: accessed May 23, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.