Does plutonium intake in workers affect lymphocyte function

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Measurements of mononuclear cells in peripheral blood of persons with long term internal depositions of plutonium indicate a preferential reduction in suppressor T-lymphocytes (T/sub s/) in some individuals. The decrease in T/sub s/ cells is apparently due to altered radiosensitivity, which is domonstrated in cultured cells subjected to in vitro x-ray radiation. The increase in ratios correlates with the quantity of plutonium deposition in these subjects, but there are wide individual differences. Confirmatory studies are needed in other persons with long term alpha or chronic gamma radiation exposure. If confirmed, the implications would include recognition of a potential mechanism for ... continued below

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Pages: 16

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Voelz, G.L.; Stevenson, A.P. & Stewart, C.C. January 1, 1988.

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Description

Measurements of mononuclear cells in peripheral blood of persons with long term internal depositions of plutonium indicate a preferential reduction in suppressor T-lymphocytes (T/sub s/) in some individuals. The decrease in T/sub s/ cells is apparently due to altered radiosensitivity, which is domonstrated in cultured cells subjected to in vitro x-ray radiation. The increase in ratios correlates with the quantity of plutonium deposition in these subjects, but there are wide individual differences. Confirmatory studies are needed in other persons with long term alpha or chronic gamma radiation exposure. If confirmed, the implications would include recognition of a potential mechanism for an enhanced immune system reactivity in some individuals exposed to chronic low level radiation. 13 refs., 1 fig., 1 tab.

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Pages: 16

Notes

NTIS, PC A03/MF A01; 1.

Source

  • Workshop on biological assessment of occupational exposure to actinides, Versailles, France, 30 May 1988

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  • Other: DE88010941
  • Report No.: LA-UR-88-1598
  • Report No.: CONF-880514-1
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 5102796
  • Archival Resource Key: ark:/67531/metadc1053521

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 1, 1988

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  • Jan. 22, 2018, 7:23 a.m.

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  • Feb. 1, 2018, 7:04 p.m.

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Voelz, G.L.; Stevenson, A.P. & Stewart, C.C. Does plutonium intake in workers affect lymphocyte function, article, January 1, 1988; New Mexico. (digital.library.unt.edu/ark:/67531/metadc1053521/: accessed April 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.