Oral Supplementation with Baker's Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise

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This article discusses a study to determine if 10 days of oral supplementation with Baker's yeast beta glucan (BYBG) could modify previously observed suppression of monocytes, T cells, circulating and whole blood LPS-stimulated cytokines due to strenuous exercise.

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13 p.

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McFarlin, Brian K.; Venable, Adam S.; Carpenter, Katie C.; Henning, Andrea L. & Ogenstad, Stephan October 20, 2017.

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This article discusses a study to determine if 10 days of oral supplementation with Baker's yeast beta glucan (BYBG) could modify previously observed suppression of monocytes, T cells, circulating and whole blood LPS-stimulated cytokines due to strenuous exercise.

Physical Description

13 p.

Notes

Abstract: Exercise and physical labor in extreme environmental conditions causes transient
decreases in immune cell and cytokine concentrations, likely increasing the susceptibility
to opportunistic infection. Baker’s yeast beta glucan (BYBG) has been previously
demonstrated to be an effective countermeasure in athletes, but its effectiveness in
individuals of average fitness under similar physical stress is unknown. The purpose
of this study was to determine if 10 days of oral supplementation with BYBG could
modify previously observed suppression of monocytes, T cells, circulating and whole
blood LPS-stimulated cytokines due to strenuous exercise. Venous blood samples were
collected from 109 healthy volunteers prior to, immediately after, 2 and 4 h post-exercise.
Monocyte and T cell concentration, cell-surface receptor expression and serum and
LPS-stimulated cytokines were assessed. BYBG significantly (P < 0.05) altered total
and classic monocyte concentration and expression of CD38, CD80, CD86, TLR2,
and TLR4 on monocyte subsets. BYBG also significantly increased CD4+ and CD8+
T cell concentration and the exercise response of CCR7+/CD45RA- central memory
(TCM) cells. Likewise, BYBG significantly (P < 0.05) altered serum IFN-g and IL-2,
and LPS-stimulated IFN-g, IL-2, IL-4, and IL-7. Taken together these data support the
hypothesis that oral BYBG supplementation modulates the expected exercise response
for individuals of average fitness. This may result in a decrease in susceptibility to
opportunistic infections after strenuous exercise.

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  • Frontiers in Physiology, 2017. Lausanne, Switzerland: Frontiers Research Foundation

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  • Publication Title: Frontiers in Physiology
  • Volume: 8
  • Pages: 1-13
  • Peer Reviewed: Yes

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  • April 7, 2017

Accepted Date

  • September 25, 2017

Creation Date

  • October 20, 2017

Added to The UNT Digital Library

  • Nov. 15, 2017, 11:13 a.m.

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McFarlin, Brian K.; Venable, Adam S.; Carpenter, Katie C.; Henning, Andrea L. & Ogenstad, Stephan. Oral Supplementation with Baker's Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise, article, October 20, 2017; Lausanne, Switzerland. (digital.library.unt.edu/ark:/67531/metadc1040505/: accessed July 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Education.