MYOCARDIAL SCANNING WITH $sup 82$Rb. Page: 4 of 10
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NH4%H302. The resin column was connected to a 20-m1 syringe which was
automatically filled from an eluant reservoir and emptied through the
isotope generator by an electric motor drive and automatic two-way valve.
With this automatic elution system, controlled flow of the eluant solution
under sterile conditions is achieved through a closed system. The flow
rate of the eluant was set at 0.33 ml/sec to allow for resistance to flow
from the ion-exchange resin and yet deliver gBb to the desired site before
it decayed away. As the eluant came from the column it was delivered
through intramedic polyethylene tubing of about 0.030 inch i.d. to a sterile
three-way valve and 0.22 p Millipore filter and into a peripheral vein.
In the studies illustrated in the figures, 4 ml of 0.3 M NH4C2H302 and
82b solution was given and pictu.-es started 2.5 or 3 minutes later end
exposed for 5-8 minutes. The first subject shown in Fig. 3 received 2
infusions of 4 ml each, the picture being started 3 minutes after and
exposed for 5-1/2 minutes in each case (total exposure 11 minutes) without
moving the subject.
The feasibility of gRb for myocardial visualization has been
demonstrated in 7 animal species (rat, rabbit, monkey, dog, pig, goat, and
chimpanzee). Type or depth of anesthesia was not a significant factor.
Uptake in tha normal monkey heart is shown in Fig. 2B.
Ten normal humans and 6 patients with myocardial disease studied
to date have shown little uptake of thrs isotope in the myocardium. Three
of the sixteen subjects showed some uptake of $82b in the myocardium and
one showed very good uptake in the myocardium. The remaining twelve patients
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Bokelman, J.; Van Dyke, D.; Yano, Y. & Anger, H. MYOCARDIAL SCANNING WITH $sup 82$Rb., report, January 1, 1972; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc1032549/m1/4/: accessed December 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.